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Mebeverine hydrochloride

Name: Mebeverine hydrochloride
Brand: TargetMol
SKU: T1053
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1053Cas No. 2753-45-9

Alias Duspatalin Hydrochloride, Duspatal Hydrochloride, Colofac Hydrochloride

Mebeverine hydrochloride (Colofac Hydrochloride), a β-phenylethylamine derivative, is a potent α1 repector inhibitor, relaxing the muscles in and around the gut.

Mebeverine hydrochloride

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Purity: 99.81%

Catalog No. T1053Alias Duspatalin Hydrochloride, Duspatal Hydrochloride, Colofac HydrochlorideCas No. 2753-45-9

Mebeverine hydrochloride (Colofac Hydrochloride), a β-phenylethylamine derivative, is a potent α1 repector inhibitor, relaxing the muscles in and around the gut.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$37	In Stock	In Stock
50 mg	$55	In Stock	In Stock
100 mg	$83	In Stock	In Stock
500 mg	$183	In Stock	In Stock
1 g	$289	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$37	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.81%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Mebeverine hydrochloride AI Summary

Mebeverine hydrochloride is involved in various bioactivities with potential therapeutic applications. It has demonstrated potency in modulating Lamin A splicing and lipid storage in Drosophila S3 cells. The compound acts as an inhibitor of AmpC Beta-Lactamase activity, Cytochrome P450 3A4 activator, and phosphatase activity of Eya2. It also shows delayed death inhibition of the malarial parasite plastid and inhibits Cell Surface uPA Generation. Additionally, Mebeverine hydrochloride induces DNA re-replication in normal breast cells and colon adenocarcinoma cells, and inhibits Hepatitis C Virus. It exhibits activity in inducing synthetic lethality in tumor cells and blocks Marburg Virus entry. The compound affects K+ channel activity and insulin secretion in INS-1E cells under different glucose conditions, and influences DNA content and chromatin condensation in HeLa cells. Notably, Mebeverine hydrochloride shows significant inhibition of sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells at a concentration of 10 µM, with inhibition percentages of 89.99% and 111.98%, respectively. In tests conducted on Vero E6 cells infected with SARS-CoV-2, Mebeverine hydrochloride demonstrated an inhibition index of 0.9476, indicating lower activity in inhibiting cell viability compared to the arbidol control. These bioactivities underscore Mebeverine hydrochloride's diverse, potent biological activities across different cell types and experimental conditions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Mebeverine hydrochloride (Colofac Hydrochloride), a β-phenylethylamine derivative, is a potent α1 repector inhibitor, relaxing the muscles in and around the gut.
Synonyms	Duspatalin Hydrochloride, Duspatal Hydrochloride, Colofac Hydrochloride

Chemical Properties

Molecular Weight	429.55
Formula	C₂₅H₃₅NO₅
Cas No.	2753-45-9
Smiles	CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc1ccc(OC)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (69.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3280 mL	11.6401 mL	23.2802 mL	116.4009 mL
5 mM	0.4656 mL	2.3280 mL	4.6560 mL	23.2802 mL
10 mM	0.2328 mL	1.1640 mL	2.3280 mL	11.6401 mL
20 mM	0.1164 mL	0.5820 mL	1.1640 mL	5.8200 mL
50 mM	0.0466 mL	0.2328 mL	0.4656 mL	2.3280 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc