B7-H2/ICOSLG Protein, Human, Recombinant

Catalog No. TMPY-06813

ICOS ligand Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.69 kDa and the accession number is NP_056074.1.

B7-H2/ICOSLG Protein, Human, Recombinant

Catalog No. TMPY-06813

ICOS ligand Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.69 kDa and the accession number is NP_056074.1.

Pack Size	Price	Availability
5 μg	$58	7-10 days
10 μg	$93	7-10 days
20 μg	$152	7-10 days
50 μg	$298	7-10 days
100 μg	$577	7-10 days

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Product Information

Biological Activity	Immobilized Recombinant Human ICOS ligand Protein (ECD) at 2 μg/ml (100 μl/well) can bind Recombinant Human ICOS / AILIM / CD278 Protein (His & Fc Tag) , the EC50 is 8-25 ng/mL.
Description	ICOS ligand Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.69 kDa and the accession number is NP_056074.1.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	NP_056074.1
Synonyms	LICOS,inducible T-cell co-stimulator ligand,ICOSLG,ICOS-L,ICOSL,ICOS ligand,GL50,CD275,B7RP-1,B7RP1,B7-h2,B7H2
Construction	A DNA sequence encoding the human ICOS ligand (NP_056074.1) (Met1-Ser258) was expressed. Predicted N terminal: Asp 19
Protein Purity	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
Molecular Weight	26.69 kDa (predicted); 47.51 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy