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Anti-VCAM-1 Antibody (8I177)
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Catalog No. TMAY-00286
Alias VCAM-1, vascular cell adhesion molecule 1, INCAM-100, CD106
Anti-VCAM-1 Antibody (8I177) is a Mouse antibody targeting VCAM-1. Anti-VCAM-1 Antibody (8I177) can be used in ELISA,ELISA(Det),IHC-P.
Anti-VCAM-1 Antibody (8I177)
Anti-VCAM-1 Antibody (8I177)
😃Good
Catalog No. TMAY-00286Alias VCAM-1, vascular cell adhesion molecule 1, INCAM-100, CD106
Anti-VCAM-1 Antibody (8I177) is a Mouse antibody targeting VCAM-1. Anti-VCAM-1 Antibody (8I177) can be used in ELISA,ELISA(Det),IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $70 | 7-10 days | |
| 100 μL | $198 | 7-10 days |
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Chemical Properties
| Description | Anti-VCAM-1 Antibody (8I177) is a Mouse antibody targeting VCAM-1. Anti-VCAM-1 Antibody (8I177) can be used in ELISA,ELISA(Det),IHC-P. |
| Synonyms | VCAM-1, vascular cell adhesion molecule 1, INCAM-100, CD106 |
| Ig Type | Mouse IgG1 |
| Clone | 8I177 |
| Reactivity | Human |
| Specificity | Human VCAM-1/CD106 |
| Verified Activity | 1. Immunochemical staining of human VCAM1 in human tonsil with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human VCAM1 in human spleen with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human VCAM1 in human kidney with mouse monoclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Application | |
| Recommended Dose | ELISA: 1:1000-1:2000; IHC-P: 1:200-1:2000; ELISA(Det): 1:1000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human VCAM1/VCAM-1/CD106 (rh VCAM1/VCAM-1/CD106; NP_001069.1Met1-Pro697). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. Two forms of VCAM-1 with either six or seven extracellular Ig-like domains are generated by alternative splicing, with the longer form predominant. VCAM-1 is an endothelial ligand for very late antigen-4 (VLA-4) and α4ß7 integrin expressed on leukocytes, and thus mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 expression is induced on endothelial cells during inflammatory bowel disease, atherosclerosis, allograft rejection, infection, and asthmatic responses. During these responses, VCAM-1 forms a scaffold for leukocyte migration. VCAM-1 also activates signals within endothelial cells resulting in the opening of an "endothelial cell gate" through which leukocytes migrate. VCAM-1 has been identified as a potential anti-inflammatory therapeutic target, the hypothesis being that reduced expression of VCAM-1 will slow the development of atherosclerosis. In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Others Formats | HRP |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Protein: Human VCAM1/VCAM-1/CD106 Protein |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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