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AM 374

Name: AM 374
Brand: TargetMol
SKU: T68492
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T68492Cas No. 86855-26-7

Alias Hexadecanesulfonyl fluoride, HDSF

AM 374 (HDSF), a fatty acid amide hydrolase (FAAH) inhibitor, demonstrates the capacity to inhibit amidase activity, boasting an IC50 value of 13 nM. This compound is potentially applicable in neurological disease research.

AM 374

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Purity: 97.08%

Catalog No. T68492Alias Hexadecanesulfonyl fluoride, HDSFCas No. 86855-26-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	-	In Stock
10 mg	$67	In Stock	In Stock
25 mg	$138	In Stock	In Stock
50 mg	$222	-	In Stock
100 mg	$328	-	In Stock
1 mL x 10 mM (in DMSO)	$43	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.08%

Appearance:Oil

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	AM 374 (HDSF), a fatty acid amide hydrolase (FAAH) inhibitor, demonstrates the capacity to inhibit amidase activity, boasting an IC50 value of 13 nM. This compound is potentially applicable in neurological disease research.
Targets&IC50	Amidase:13 nM
In vitro	AM 374 (0-9 nM) inhibits anandamide degradation in N18TG2 cells. [1]
In vivo	AM 374 (20 μg ; intraventricular injection, once) has no effect on lever pressing in FR5, but when used in combination with anandamide (intraperitoneal injection), it reduces lever pressing.[2]
Synonyms	Hexadecanesulfonyl fluoride, HDSF

Chemical Properties

Molecular Weight	308.5
Formula	C₁₆H₃₃FO₂S
Cas No.	86855-26-7
Smiles	CCCCCCCCCCCCCCCCS(F)(=O)=O

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (202.59 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2415 mL	16.2075 mL	32.4149 mL	162.0746 mL
5 mM	0.6483 mL	3.2415 mL	6.4830 mL	32.4149 mL
10 mM	0.3241 mL	1.6207 mL	3.2415 mL	16.2075 mL
20 mM	0.1621 mL	0.8104 mL	1.6207 mL	8.1037 mL
50 mM	0.0648 mL	0.3241 mL	0.6483 mL	3.2415 mL
100 mM	0.0324 mL	0.1621 mL	0.3241 mL	1.6207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc