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LYTACs

Lysosomal-Targeting Chimeras (LYTACs) can target extracellular proteins. LYTACs and MoDE-As tether extracellular or membrane-bound POIs to a recycling receptor, which facilitates internalization and subsequent lysosomal degradation. LYTACs utilize the cation-independent mannose-6-phosphate receptor CI-M6PR, a recycling membrane protein that binds POIs labeled with an MP6n tag. GalNAc-LYTACs and MoDE-As utilize a GalNAC tag to recruit the asialoglycoprotein receptor (ASGPR), a liver-specific lysosomal targeting receptor, for tissue-specific degradation.

  • tri-GalNAc-COOH
    T393701953146-81-0In house
    Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
    • $255
    In Stock
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  • Tri-GalNAc-NHS ester
    T809461953146-83-2
    Tri-GalNAc-NHS ester, a LYsosome TArgeting Chimera (LYTAC) and ligand for the asialoglycoprotein receptor (ASGPR), facilitates the degradation of extracellular proteins, including membrane proteins, via the lysosomal targeting receptor expressed on liver cells. This compound is utilized as a protein degrader in LYTAC research [1].
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  • tri-GalNAc-COOH (acetylation)
    T80947
    Tri-GalNAc-COOH acetylation represents the acetylated derivative of tri-galactosamine (tri-GalNAc-COOH), utilized in the synthesis of lysosome targeting chimeras (LYTAC).
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  • M-MoDE-A (2)
    T817792378837-56-8
    M-MoDE-A (2) is a bifunctional small molecule that facilitates the degradation of extracellular proteins via the asialoglycoprotein receptor (ASGPR).
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  • Tri-GalNAc(OAc)3-Perfluorophenyl
    T77935
    Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl-modified triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand utilized in the synthesis of GalNAc-lysosome-targeting chimeras (LYTACs). These chimeras facilitate targeted protein degradation through engagement with the asialoglycoprotein receptor [1].
    • $1,960
    5 days
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  • Tri-GalNAc(OAc)3 TFA
    T779471159408-65-7
    Tri-GalNAc(OAc)3 TFA, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome-targeting chimera (GalNAc-LYTAC). This compound facilitates targeted protein degradation by engaging with the asialoglycoprotein receptor [1].
    • $74
    Backorder
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  • D-MoDE-A (1)
    T825372378837-67-1
    D-MoDE-A (1) is a bifunctional small molecule that facilitates extracellular protein degradation via the asialoglycoprotein receptor (ASGPR).
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  • TriGalNAc CBz
    T77945186613-57-0
    TriGalNAc CBz is a GalNAc derivative. As an ASGPR ligand, tri-GalNAc targets lysosomes in mRNA drug delivery and LYTAC studies.L-DABA hydrobromide.
    • $30
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  • tri-GalNAc biotin
    T77941
    Tri-GalNAc biotin, a small molecule lysosome targeting degrader, serves as a ligand for the asialoglycoprotein receptor (ASGPR). It promotes the uptake of NeutrAvidin (NA) into liver cells via ASGPR and directs NeutrAvidin to the lysosome for degradation. This compound is applicable in the study of Lysosome Targeting Chimeras (LYTAC) [1].
    • $1,960
    35 days
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  • Tri-GalNAc(OAc)3
    T779461159408-64-6
    Tri-GalNAc(OAc)3, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome targeting chimeras (LYTAC). These chimeras exploit the asialoglycoprotein receptor to direct protein degradation targets to the lysosome [1].
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