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LYTACs
Lysosomal-Targeting Chimeras (LYTACs) can target extracellular proteins. LYTACs and MoDE-As tether extracellular or membrane-bound POIs to a recycling receptor, which facilitates internalization and subsequent lysosomal degradation. LYTACs utilize the cation-independent mannose-6-phosphate receptor CI-M6PR, a recycling membrane protein that binds POIs labeled with an MP6n tag. GalNAc-LYTACs and MoDE-As utilize a GalNAC tag to recruit the asialoglycoprotein receptor (ASGPR), a liver-specific lysosomal targeting receptor, for tissue-specific degradation.
tri-GalNAc-COOH
T393701953146-81-0In house
Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) and is commonly used in lysosomal targeting chimera (LYTAC) investigations.
- $243
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TriGalNAc CBz
T77945186613-57-0
TriGalNAc CBz is a GalNAc derivative. As an ASGPR ligand, tri-GalNAc targets lysosomes in mRNA drug delivery and LYTAC studies.L-DABA hydrobromide.
- $41
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Tri-GalNAc-DBCO
T779482999748-27-3
Tri-GalNAc-DBCO is a PIP-GalNAc coupling compound that binds ASGPR to drive protein down-regulation and target compounds for protein degradation via copper-free strain-promoted azide-alkyne cycloaddition coupled to azide on a non-specifically labeled antibody.
- $499
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Mal-C2-amide-C10-tri-GalNAc
T2190542893765-20-1
Mal-C2-amide-C10-tri-GalNAc is an asialoglycoprotein receptor (ASGPR) binding ligand fragment and a component of lysosome-targeting bifunctional molecules (LYTACs). Mal-C2-amide-C10-tri-GalNAc can promote the sequestration and degradation of extracellular target molecules in lysosomes and can be used in autoimmune disease research.
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tri-GalNAc-COOH (acetylation)
T80947
Tri-GalNAc-COOH acetylation represents the acetylated derivative of tri-galactosamine (tri-GalNAc-COOH), utilized in the synthesis of lysosome targeting chimeras (LYTAC).
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tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12)
T215187
Tri(GalNAc-PEG2)-PEG4-cyclo(Ac-DCAW-{Arg(3F-Ph)-PEG2}-LGELVWCT) (Cys2-Cys12) is a ligand for asialoglycoprotein receptors (ASGPR) applicable in lysosome-targeting chimera (LYTAC) research.
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Tri-GalNAc-NHS ester
T809461953146-83-2
Tri-GalNAc-NHS ester is a high-affinity triantennary N-acetylgalactosamine (GalNAc) derivative acting as a specific ligand for the Asialoglycoprotein Receptor (ASGPR) with a Kd of approximately 2.5 nM, which conjugates to antibodies via the NHS ester moiety to construct Lysosome Targeting Chimeras (LYTACs) for the liver-specific degradation of extracellular proteins.
- $336
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dPDL1-4
T211758
dPDL1-4 is a potent and selective eHSPTAC eHSP90PD-L1 degrader, with DC50 values of 7.77 μM (HeLa) and 6.52 μM (B16F10). It links eHSP90 to target proteins, inducing lysosomal degradation. dPDL1-4 effectively degrades PD-L1 and inhibits tumor growth, making it useful for research in cervical cancer and melanoma.
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M-MoDE-A (2)
T817792378837-56-8
M-MoDE-A (2) is a bifunctional small molecule that promotes the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).
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L96-OH
TSW-011881159408-72-6
L96-OH is a trivalent acetylated GalNAc linker with a free hydroxyl group at one end; this terminal hydroxyl group can be used for solid-phase synthesis or for coupling with molecules bearing reactive groups, making it a key intermediate in the preparation of GalNAc-conjugated oligonucleotides (such as ASOs or siRNAs).
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Tri-GalNAc(OAc)3-Perfluorophenyl
T77935
Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl-modified triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand utilized in the synthesis of GalNAc-lysosome-targeting chimeras (LYTACs). These chimeras facilitate targeted protein degradation through engagement with the asialoglycoprotein receptor [1].
- $1,960
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GalNac-siRNA negative control (21nt)
T217364
GalNac-siRNA negative control (21nt) serves as the negative control form of GalNac-siRNA. GalNac-siRNA is an inhibitor conjugate targeting the asialoglycoprotein receptor (ASGPR). This compound holds potential for research into hereditary transthyretin amyloidosis, acute hepatic porphyria, hemophilia, and hypercholesterolemia.
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Tri-GalNAc(OAc)3
T779461159408-64-6
Tri-GalNAc(OAc)3, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome targeting chimeras (LYTAC). These chimeras exploit the asialoglycoprotein receptor to direct protein degradation targets to the lysosome [1].
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D-MoDE-A (1)
T825372378837-67-1
D-MoDE-A (1) is a bifunctional small molecule that promotes extracellular protein degradation through the asialoglycoprotein receptor (ASGPR).
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ASGPR ligand-1
T829591426160-58-8
ASGPR ligand-1 is a compound that targets the asialoglycoprotein receptor (ASGPR) and is utilized in various disease research contexts [1].
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Tri-GalNAc(OAc)3 TFA
T779471159408-65-7
Tri-GalNAc(OAc)3 TFA, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome-targeting chimera (GalNAc-LYTAC). This compound facilitates targeted protein degradation by engaging with the asialoglycoprotein receptor [1].
- $54
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Allyl-mannose-6-phosphonate
T2171273030990-46-3
Allyl-mannose-6-phosphonate (M6Pn; Compound 6) is a stable analog of mannose-6-phosphate (M6P). It is utilized in the synthesis of M6Pn-peptide conjugates for the construction of lysosome-targeting chimeras (LYTAC).
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Peracetylated GlcNAc-C5-Amide-C3-NH-Cbz
TSW-011871637413-95-6
Peracetylated GlcNAc-C5-Amide-C3-NH-Cbz is an acetylated monosaccharide (GalNAc) building block bearing a Cbz (benzyloxycarbonyl) protecting group; its terminal amino group is protected. After removal of the Cbz group, it can be used to stepwise construct multivalent GalNAc-targeted ligands or as a precursor for the synthesis of oligonucleotide modifications.
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tri-GalNAc biotin
T77941
Tri-GalNAc biotin, a small molecule lysosome targeting degrader, serves as a ligand for the asialoglycoprotein receptor (ASGPR). It promotes the uptake of NeutrAvidin (NA) into liver cells via ASGPR and directs NeutrAvidin to the lysosome for degradation. This compound is applicable in the study of Lysosome Targeting Chimeras (LYTAC) [1].
- $2,400
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