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APX-115

Name: APX-115
Brand: TargetMol
SKU: T10354
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10354Cas No. 1395946-75-4

Alias Ewha-18278

APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.

APX-115

🥰Excellent

Purity: 98.62%

Catalog No. T10354Alias Ewha-18278Cas No. 1395946-75-4

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$73	In Stock
10 mg	$118	In Stock
25 mg	$247	In Stock
50 mg	$370	In Stock
100 mg	$527	In Stock
500 mg	$1,070	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.62%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
Targets&IC50	NOX2:0.57 μM (ki), Nox4:0.63 μM (ki), NOX1:ki:1.08 μM
In vitro	In the mouse podocyte cell line, APX-115 (5 μM; 60 min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression. In the kidney, APX-115 attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes [2].
In vivo	APX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. APX-115 (oral gavage; 60 mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice[1].
Synonyms	Ewha-18278

Chemical Properties

Molecular Weight	315.8
Formula	C₁₇H₁₈ClN₃O
Cas No.	1395946-75-4
Smiles	Cl.CCCc1c(O)n(nc1-c1ccccc1)-c1ccccn1
Relative Density.	no data available
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (285 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1666 mL	15.8328 mL	31.6656 mL	158.3281 mL
5 mM	0.6333 mL	3.1666 mL	6.3331 mL	31.6656 mL
10 mM	0.3167 mL	1.5833 mL	3.1666 mL	15.8328 mL
20 mM	0.1583 mL	0.7916 mL	1.5833 mL	7.9164 mL
50 mM	0.0633 mL	0.3167 mL	0.6333 mL	3.1666 mL
100 mM	0.0317 mL	0.1583 mL	0.3167 mL	1.5833 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc