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KAT6-IN-1
🥰Excellent
Catalog No. T75146Cas No. 2569008-99-5
Alias Prifetrastat, PF-07248144, PF07248144
KAT6-IN-1 (compound E) is a selective, orally available inhibitor of histone acetyltransferases KAT6A and KAT6B, exhibiting antitumour activity for cancer research.
KAT6-IN-1
🥰Excellent
Purity: 99.86%
Catalog No. T75146Alias Prifetrastat, PF-07248144, PF07248144Cas No. 2569008-99-5
KAT6-IN-1 (compound E) is a selective, orally available inhibitor of histone acetyltransferases KAT6A and KAT6B, exhibiting antitumour activity for cancer research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $100 | - | In Stock | |
| 5 mg | $247 | - | In Stock | |
| 10 mg | $396 | - | In Stock | |
| 25 mg | $787 | - | In Stock | |
| 50 mg | $1,230 | - | In Stock | |
| 100 mg | $1,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.86%
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Product Introduction
Bioactivity
Chemical Properties
| Description | KAT6-IN-1 (compound E) is a selective, orally available inhibitor of histone acetyltransferases KAT6A and KAT6B, exhibiting antitumour activity for cancer research. |
| In vitro | The combination of KAT6-IN-1 and Palbociclib exerts synergistic inhibitory effects on T47D, ZR-75-1, CAMA1, and MCF7 cancer cells [2]. |
| In vivo | In the mouse ST340 Parazacco spilurus subsp. spilurus transplantation model, KAT6-IN-1 (3 mg/kg, orally administered once daily for 21 days) demonstrated antitumor activity [2]. |
| Synonyms | Prifetrastat, PF-07248144, PF07248144 |
| Molecular Weight | 414.43 |
| Formula | C19H18N4O5S |
| Cas No. | 2569008-99-5 |
| Smiles | O=S(=O)(NC1=NOC2=CC(=CC(OC)=C21)CN3N=CC=C3)C=4C=CC=CC4OC |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 3 mg/mL (7.24 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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