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GDC-0623

Name: GDC-0623
Brand: TargetMol
SKU: T6843
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6843Cas No. 1168091-68-6

Alias RG 7421, MEK inhibitor 1, GDC0623, G-868

GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1.

GDC-0623

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Purity: 99.02%

Catalog No. T6843Alias RG 7421, MEK inhibitor 1, GDC0623, G-868Cas No. 1168091-68-6

GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
2 mg	$67	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$295	In Stock	In Stock
50 mg	$388	In Stock	In Stock
100 mg	$645	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$122	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.02%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1.
Targets&IC50	MEK1:0.13 nM(ki)
Synonyms	RG 7421, MEK inhibitor 1, GDC0623, G-868

Chemical Properties

Molecular Weight	456.21
Formula	C₁₆H₁₄FIN₄O₃
Cas No.	1168091-68-6
Smiles	OCCONC(=O)c1ccc2cncn2c1Nc1ccc(I)cc1F
Relative Density.	1.81 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 5 mg/mL (10.96 mM), Sonication is recommended.

DMSO: 91 mg/mL (199.47 mM), Heating is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1920 mL	10.9599 mL	21.9197 mL	109.5986 mL
5 mM	0.4384 mL	2.1920 mL	4.3839 mL	21.9197 mL
10 mM	0.2192 mL	1.0960 mL	2.1920 mL	10.9599 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1096 mL	0.5480 mL	1.0960 mL	5.4799 mL
50 mM	0.0438 mL	0.2192 mL	0.4384 mL	2.1920 mL
100 mM	0.0219 mL	0.1096 mL	0.2192 mL	1.0960 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc