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GDC-0623

Name: GDC-0623
Brand: TargetMol
SKU: T6843
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6843Cas No. 1168091-68-6

Alias RG 7421, MEK inhibitor 1, GDC0623, G-868

GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1.

GDC-0623

🥰Excellent

Purity: 99.02%

Catalog No. T6843Alias RG 7421, MEK inhibitor 1, GDC0623, G-868Cas No. 1168091-68-6

GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
2 mg	$67	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$295	In Stock	In Stock
50 mg	$388	In Stock	In Stock
100 mg	$645	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$122	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.02%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	GDC-0623 (RG 7421) is a potent, ATP-uncompetitive MEK1 inhibitor with a Ki of 0.13 nM, currently in Phase 1.
Targets&IC50	MEK1:0.13 nM(ki)
Synonyms	RG 7421, MEK inhibitor 1, GDC0623, G-868

Chemical Properties

Molecular Weight	456.21
Formula	C₁₆H₁₄FIN₄O₃
Cas No.	1168091-68-6
Smiles	OCCONC(=O)c1ccc2cncn2c1Nc1ccc(I)cc1F
Relative Density.	1.81 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 5 mg/mL (10.96 mM), Sonication is recommended.

DMSO: 91 mg/mL (198.82 mM), Heating is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.23 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1920 mL	10.9599 mL	21.9197 mL	109.5986 mL
5 mM	0.4384 mL	2.1920 mL	4.3839 mL	21.9197 mL
10 mM	0.2192 mL	1.0960 mL	2.1920 mL	10.9599 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1096 mL	0.5480 mL	1.0960 mL	5.4799 mL
50 mM	0.0438 mL	0.2192 mL	0.4384 mL	2.1920 mL
100 mM	0.0219 mL	0.1096 mL	0.2192 mL	1.0960 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc