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Zotatifin

Name: Zotatifin
Brand: TargetMol
SKU: T17296
Price: 1090 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17296Cas No. 2098191-53-6

Alias eFT226, eFT 226

Zotatifin (eFT226) is a selective eIF4A inhibitor with antiviral and anticancer activities, blocking tumor growth driven by receptor tyrosine kinases and inhibiting Sox4 translation, inducing apoptosis.

Zotatifin

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Purity: 98.85%

Catalog No. T17296Alias eFT226, eFT 226Cas No. 2098191-53-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$1,090	In Stock	In Stock
5 mg	$3,150	In Stock	In Stock
10 mg	$4,930	In Stock	In Stock
25 mg	$7,490	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.85%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Zotatifin (eFT226) is a selective eIF4A inhibitor with antiviral and anticancer activities, blocking tumor growth driven by receptor tyrosine kinases and inhibiting Sox4 translation, inducing apoptosis.
Targets&IC50	eIF4A:2 nM
In vitro	Methods: Zotatifin (0.0001 μM-1 μM, 72 hours) was used to treat MDA-MB-231 cells, and the antiproliferative activity was determined. Results: Zotatifin showed potent antiproliferative activity in MDA-MB-231 tumor cells, with a GI50 value of less than 15 nM. TMD8 and Pfeiffer DLBCL tumor cells were treated with Zotatifin (30 μM-100 μM, 3 or 24 hours), and the changes in protein levels were detected by WB. Results: Zotatifin reduced the expression of MYC, CCND3, BCL2, and MCL1 proteins in a time- and dose-dependent manner.[1]
In vivo	Methods: Zotatifin (1 mg/kg, intravenous injection, 14-22 days) was used to treat mice bearing TMD8 xenografts, HBL1 xenografts, Pfeiffer xenografts, SU-DHL-6 xenografts, SU-DHL-10 xenografts, and Ramos xenografts, and the tumor inhibition rate was observed. Results: The tumor growth percentages of various tumor xenograft model mice after Zotatifin treatment were 97%, 87%, 70%, 83%, 37%, and 75%, respectively. Methods: Zotatifin (0.001 mg/kg-1 mg/kg, intravenous injection; 15 days) was used to treat mice bearing B-cell lymphoma xenograft models, and the tumor growth in vivo was observed. Results: Zotatifin inhibited the growth of B-cell lymphoma xenografts and was well tolerated in B-cell lymphoma xenograft models in vivo.[2]
Synonyms	eFT226, eFT 226

Chemical Properties

Molecular Weight	487.55
Formula	C₂₈H₂₉N₃O₅
Cas No.	2098191-53-6
Smiles	O[C@]12[C@]([C@@H]([C@@H](CN(C)C)[C@H]1O)C3=CC=CC=C3)(OC=4C2=C(OC)N=C(OC)C4)C5=CC=C(C#N)C=C5
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (307.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0511 mL	10.2554 mL	20.5107 mL	102.5536 mL
5 mM	0.4102 mL	2.0511 mL	4.1021 mL	20.5107 mL
10 mM	0.2051 mL	1.0255 mL	2.0511 mL	10.2554 mL
20 mM	0.1026 mL	0.5128 mL	1.0255 mL	5.1277 mL
50 mM	0.0410 mL	0.2051 mL	0.4102 mL	2.0511 mL
100 mM	0.0205 mL	0.1026 mL	0.2051 mL	1.0255 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc