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S-Nitroso-N-acetyl-DL-penicillamine

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Catalog No. T12808Cas No. 67776-06-1
Alias SNAP

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.

S-Nitroso-N-acetyl-DL-penicillamine
Other Forms of S-Nitroso-N-acetyl-DL-penicillamine:

S-Nitroso-N-acetyl-DL-penicillamine

🥰Excellent
Purity: 97.42%
Catalog No. T12808Alias SNAPCas No. 67776-06-1
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$41In StockIn Stock
25 mg$57In StockIn Stock
50 mg$93In StockIn Stock
100 mg$166In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:97.42%
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Product Introduction

Bioactivity
Description
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.
In vitro
S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces approximately 80% toxicity under normoxic conditions by releasing nitric oxide (NO) after 6 hours [1]. It has a half-life of about 6 hours in isolated rat ventricular myocytes [3] and, at 100 μM for 30 minutes, causes a sustained decrease in basal pHi in these cells [3].
SynonymsSNAP
Chemical Properties
Molecular Weight220.25
FormulaC7H12N2O4S
Cas No.67776-06-1
SmilesCC(=O)NC(C(O)=O)C(C)(C)SN=O
Relative Density.1.4261 g/cm3 (Estimated)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 3.45 mg/mL (15.66 mM), Sonication is recommended.
DMSO: 250 mg/mL (1135.07 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (22.7 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM4.5403 mL22.7015 mL45.4030 mL227.0148 mL
5 mM0.9081 mL4.5403 mL9.0806 mL45.4030 mL
10 mM0.4540 mL2.2701 mL4.5403 mL22.7015 mL
DMSO
1mg5mg10mg50mg
20 mM0.2270 mL1.1351 mL2.2701 mL11.3507 mL
50 mM0.0908 mL0.4540 mL0.9081 mL4.5403 mL
100 mM0.0454 mL0.2270 mL0.4540 mL2.2701 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

S-Nitroso-N-acetyl-DL-penicillamineSNitrosoNacetylDLpenicillamineS Nitroso N acetyl DL penicillamineNOSynthaseNOSNO SynthaseNitric oxide synthasesInhibitorinhibit
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