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S-Nitroso-N-acetyl-DL-penicillamine

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Catalog No. T12808Cas No. 67776-06-1
Alias SNAP

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.

S-Nitroso-N-acetyl-DL-penicillamine
Other Forms of S-Nitroso-N-acetyl-DL-penicillamine:

S-Nitroso-N-acetyl-DL-penicillamine

🥰Excellent
Purity: 97.42%
Catalog No. T12808Alias SNAPCas No. 67776-06-1
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$41In StockIn Stock
25 mg$57In StockIn Stock
50 mg$93In StockIn Stock
100 mg$166In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:97.42%
Appearance:Solid
Color:Green
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
S-Nitroso-N-acetyl-DL-penicillamine (SNAP) is a stable inhibitor of platelet aggregation and a nitric oxide donor.
In vitro
S-Nitroso-N-acetyl-DL-penicillamine (10 mM; 8 hours) induces approximately 80% toxicity under normoxic conditions by releasing nitric oxide (NO) after 6 hours [1]. It has a half-life of about 6 hours in isolated rat ventricular myocytes [3] and, at 100 μM for 30 minutes, causes a sustained decrease in basal pHi in these cells [3].
SynonymsSNAP
Chemical Properties
Molecular Weight220.25
FormulaC7H12N2O4S
Cas No.67776-06-1
SmilesCC(=O)NC(C(O)=O)C(C)(C)SN=O
Relative Density.1.4261 g/cm3 (Estimated)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 3.45 mg/mL (15.66 mM), Sonication is recommended.
DMSO: 250 mg/mL (1135.07 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (22.7 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM4.5403 mL22.7015 mL45.4030 mL227.0148 mL
5 mM0.9081 mL4.5403 mL9.0806 mL45.4030 mL
10 mM0.4540 mL2.2701 mL4.5403 mL22.7015 mL
DMSO
1mg5mg10mg50mg
20 mM0.2270 mL1.1351 mL2.2701 mL11.3507 mL
50 mM0.0908 mL0.4540 mL0.9081 mL4.5403 mL
100 mM0.0454 mL0.2270 mL0.4540 mL2.2701 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

S-Nitroso-N-acetyl-DL-penicillamineSNitrosoNacetylDLpenicillamineS Nitroso N acetyl DL penicillamineNOSynthaseNOSNO SynthaseNitric oxide synthasesInhibitorinhibit
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