Amphotericin X1

Name: Amphotericin X1
Brand: TargetMol
SKU: T10311
Rating: 4.5 (1 reviews)

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Catalog No. T10311Cas No. 136135-57-4

Amphotericin X1 is a derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, Cryptococcus neoformans 451, C.parapsilosis 937A, Aspergillus niger 57A and A.fumigatus (MICs: 1 μg/mL, 1 μg/mL, 8 μg/mL, 2 μg/mL and 2 μg/mL).

Amphotericin X1

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Catalog No. T10311Cas No. 136135-57-4

Pack Size	Price	Availability	Quantity
25 mg	$22,000	2-4 weeks

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Product Introduction

Bioactivity

Description	Amphotericin X1 is a derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, Cryptococcus neoformans 451, C.parapsilosis 937A, Aspergillus niger 57A and A.fumigatus (MICs: 1 μg/mL, 1 μg/mL, 8 μg/mL, 2 μg/mL and 2 μg/mL).
Targets&IC50	A.fumigatus:2 μg/mL , Cryptococcus neoformans 451: 1 μg/mL , Aspergillus niger 57A: 2 μg/mL , C.parapsilosis 937A: 8 μg/mL , C. albicans 33/079:（MIC）1 μg/mL
In vitro	Amphotericin X1 (compound 4) exhibits antifungal activity with significantly reduced hemolytic activity (EH50: 42 μg/mL) against mammalian erythrocytes in vitro.

Chemical Properties

Molecular Weight	938.118
Formula	C₄₈H₇₅NO₁₇
Cas No.	136135-57-4
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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