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SPT-IN-1

Name: SPT-IN-1
Brand: TargetMol
SKU: T28839
Rating: 4.5 (1 reviews)

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Catalog No. T28839Cas No. 1933533-18-6

Alias SPT Inhibitor 1, SPT Imidazopyridine 1

SPT-IN-1 (compound 1) is an orally active and highly potent inhibitor of serine palmitoyl transferase (SPT) with an IC50 value of 5.19 nM against human SPT1, SPT-IN-1 is utilized in metabolic disease research to explore sphingolipid biosynthesis regulation, insulin resistance mechanisms, and therapeutic strategies for type 2 diabetes and dyslipidemia.

SPT-IN-1

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Catalog No. T28839Alias SPT Inhibitor 1, SPT Imidazopyridine 1Cas No. 1933533-18-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$596	35 days	35 days
50 mg	$2,530	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	SPT-IN-1 (compound 1) is an orally active and highly potent inhibitor of serine palmitoyl transferase (SPT) with an IC50 value of 5.19 nM against human SPT1, SPT-IN-1 is utilized in metabolic disease research to explore sphingolipid biosynthesis regulation, insulin resistance mechanisms, and therapeutic strategies for type 2 diabetes and dyslipidemia.
In vitro	In cellular assays using MCF-7 cells, SPT-IN-1 exhibited a dose-dependent inhibition of sphingolipid synthesis. The compound blocked the incorporation of C14-serine into ceramide with an EC50 of 0.98 μM. This inhibition modulated cellular levels of bioactive ceramides involved in apoptosis and cell proliferation signaling [1].
In vivo	In efficacy studies involving Sprague Dawley rats fed a cholesterol/cholic acid diet, SPT-IN-1 was administered orally twice daily for 7 days at dosages of 0-60 mg/kg. The compound dose-dependently reduced plasma ceramides and triglycerides. Furthermore, the treatment resulted in an elevation of HDL (high-density lipoprotein) levels in the systemic lipid profile [4].
Synonyms	SPT Inhibitor 1, SPT Imidazopyridine 1

Chemical Properties

Molecular Weight	364.44
Formula	C₂₂H₂₄N₂O₃
Cas No.	1933533-18-6
Smiles	O=C(O)CC=1C=CC(=CC1)C2=CC(=CN3C=CN=C23)C(=O)CCCCCC
Relative Density.	1.18 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (274.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7439 mL	13.7197 mL	27.4394 mL	137.1968 mL
5 mM	0.5488 mL	2.7439 mL	5.4879 mL	27.4394 mL
10 mM	0.2744 mL	1.3720 mL	2.7439 mL	13.7197 mL
20 mM	0.1372 mL	0.6860 mL	1.3720 mL	6.8598 mL
50 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7439 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3720 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SPT-IN-1SPTIN1SPT IN 1Imidazopyridine 1