Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

SPT-IN-1

Name: SPT-IN-1
Brand: TargetMol
SKU: T28839
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T28839Cas No. 1933533-18-6

Alias SPT Inhibitor 1, SPT Imidazopyridine 1

SPT-IN-1 (compound 1) is an orally active and highly potent inhibitor of serine palmitoyl transferase (SPT) with an IC50 value of 5.19 nM against human SPT1, SPT-IN-1 is utilized in metabolic disease research to explore sphingolipid biosynthesis regulation, insulin resistance mechanisms, and therapeutic strategies for type 2 diabetes and dyslipidemia.

SPT-IN-1

😃Good

Catalog No. T28839Alias SPT Inhibitor 1, SPT Imidazopyridine 1Cas No. 1933533-18-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$596	35 days	35 days
50 mg	$2,530	35 days	35 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	SPT-IN-1 (compound 1) is an orally active and highly potent inhibitor of serine palmitoyl transferase (SPT) with an IC50 value of 5.19 nM against human SPT1, SPT-IN-1 is utilized in metabolic disease research to explore sphingolipid biosynthesis regulation, insulin resistance mechanisms, and therapeutic strategies for type 2 diabetes and dyslipidemia.
Synonyms	SPT Inhibitor 1, SPT Imidazopyridine 1

Chemical Properties

Molecular Weight	364.44
Formula	C₂₂H₂₄N₂O₃
Cas No.	1933533-18-6
Smiles	O=C(O)CC=1C=CC(=CC1)C2=CC(=CN3C=CN=C23)C(=O)CCCCCC
Relative Density.	1.18 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (274.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7439 mL	13.7197 mL	27.4394 mL	137.1968 mL
5 mM	0.5488 mL	2.7439 mL	5.4879 mL	27.4394 mL
10 mM	0.2744 mL	1.3720 mL	2.7439 mL	13.7197 mL
20 mM	0.1372 mL	0.6860 mL	1.3720 mL	6.8598 mL
50 mM	0.0549 mL	0.2744 mL	0.5488 mL	2.7439 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3720 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SPT-IN-1SPTIN1SPT IN 1Imidazopyridine 1