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Prostratin
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Catalog No. T21441Cas No. 60857-08-1
Alias 12-Deoxyphorbol-13-acetate
Prostratin (12-Deoxyphorbol-13-acetate) is an orally active protein kinase C (PKC) activator with a Ki value of 12.5 nM.As an NF-κB activator, Prostratin activates HIV gene expression in T cells.Prostratin inhibits the growth of acute myeloid leukemia (AML) cell lines and enhances cytarabine-induced AML cell differentiation. In addition, Prostratin induced KRAS phosphorylation and inhibited the growth of KRAS-mutated tumors.
Prostratin
😃Good
Catalog No. T21441Alias 12-Deoxyphorbol-13-acetateCas No. 60857-08-1
Prostratin (12-Deoxyphorbol-13-acetate) is an orally active protein kinase C (PKC) activator with a Ki value of 12.5 nM.As an NF-κB activator, Prostratin activates HIV gene expression in T cells.Prostratin inhibits the growth of acute myeloid leukemia (AML) cell lines and enhances cytarabine-induced AML cell differentiation. In addition, Prostratin induced KRAS phosphorylation and inhibited the growth of KRAS-mutated tumors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $246 | In Stock | |
| 1 mg | TBD | 35 days | |
| 5 mg | TBD | 35 days | |
| 10 mg | TBD | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Prostratin (12-Deoxyphorbol-13-acetate) is an orally active protein kinase C (PKC) activator with a Ki value of 12.5 nM.As an NF-κB activator, Prostratin activates HIV gene expression in T cells.Prostratin inhibits the growth of acute myeloid leukemia (AML) cell lines and enhances cytarabine-induced AML cell differentiation. In addition, Prostratin induced KRAS phosphorylation and inhibited the growth of KRAS-mutated tumors. |
| In vitro | Methods: Prostratin (125, 250, 500, 1000 nM) was used to treat HL-60, NB4, and U937 cells to evaluate its effect on leukemia cell growth. Results: Prostratin showed similar concentration- and time-dependent growth inhibition on all three cell lines. [2] |
| Alias | 12-Deoxyphorbol-13-acetate |
| Molecular Weight | 390.47 |
| Formula | C22H30O6 |
| Cas No. | 60857-08-1 |
| Smiles | O(C(C)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)C2)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H] |
| Relative Density. | 1.31 g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | store at 4°C | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (102.44 mM), Sonication is recommended. H2O: < 1 mg/mL (insoluble) | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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