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Rupintrivir

Name: Rupintrivir
Brand: TargetMol
SKU: T16809
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16809Cas No. 223537-30-2

Alias Rupintrivirvr, AG-7088, AG7088

Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.

Rupintrivir

🥰Excellent

Purity: 99.35%

Catalog No. T16809Alias Rupintrivirvr, AG-7088, AG7088Cas No. 223537-30-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$419	In Stock	In Stock
25 mg	$737	In Stock	In Stock
50 mg	$977	-	In Stock
100 mg	$1,290	-	In Stock
1 mL x 10 mM (in DMSO)	$347	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.35%

Resource Download

COA HPLC MS HNMR

Product Introduction

Bioactivity

Description	Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.
Targets&IC50	RD cells:0.009 μM (EC50), Vero cells:0.419 μM (EC50), H1-HeLa cells:14 nM (EC50), rhinovirus (HRV) 3C cysteine protease mimetic peptide:0.023 μM (EC50), HeLa cells:0.27 μM (EC50)
In vitro	In H1-HeLa and MRC-5 cell protection assays, Rupintrivir (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC50) of 0.023 microM (range, 0.003 to 0.081 microM) and a mean EC90 of 0.082 microM (range, 0.018 to 0.261 microM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11[1].
In vivo	PCLS from HDM-sensitized mice showed an attenuated antiviral response, but exaggerated IL-4, IL-6, and IL-10 secretion upon infection. Rupintrivir(AG7088) inhibited exaggerated pro-inflammatory cytokine IL-6 and TH-2 cytokine IL-4 in HDM-sensitized mice[2].
Synonyms	Rupintrivirvr, AG-7088, AG7088

Chemical Properties

Molecular Weight	598.66
Formula	C₃₁H₃₉FN₄O₇
Cas No.	223537-30-2
Smiles	CCOC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@@H](CC(=O)[C@@H](NC(=O)c1cc(C)on1)C(C)C)Cc1ccc(F)cc1
Relative Density.	1.31g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (421.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (3.34 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6704 mL	8.3520 mL	16.7040 mL	83.5199 mL
5 mM	0.3341 mL	1.6704 mL	3.3408 mL	16.7040 mL
10 mM	0.1670 mL	0.8352 mL	1.6704 mL	8.3520 mL
20 mM	0.0835 mL	0.4176 mL	0.8352 mL	4.1760 mL
50 mM	0.0334 mL	0.1670 mL	0.3341 mL	1.6704 mL
100 mM	0.0167 mL	0.0835 mL	0.1670 mL	0.8352 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc