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Rupintrivir

Name: Rupintrivir
Brand: TargetMol
SKU: T16809
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Rupintrivirvr, AG-7088, AG7088) Copy Product Info

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Synonyms: Rupintrivirvr, AG-7088, AG7088

Catalog No. T16809 Copy Product Info

Purity: 99.35%

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Rupintrivir (AG7088) is an antiviral agent and an irreversible inhibitor targeting human rhinovirus 3C protease (EC50 = 0.023 μM), featuring high selectivity and immunomodulatory activity, capable of effectively inhibiting multiple HRV serotypes as well as EV71 and EV-D68 replication, commonly used for research on viral infection mechanisms.

Cas No. 223537-30-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$118	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$419	In Stock	In Stock
25 mg	$737	In Stock	In Stock
50 mg	$977	-	In Stock
100 mg	$1,290	-	In Stock
1 mL x 10 mM (in DMSO)	$347	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.35%

Appearance:Solid

Color:White

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COA HPLC MS HNMR

Product Introduction

Bioactivity

Description	Rupintrivir (AG7088) is an antiviral agent and an irreversible inhibitor targeting human rhinovirus 3C protease (EC50 = 0.023 μM), featuring high selectivity and immunomodulatory activity, capable of effectively inhibiting multiple HRV serotypes as well as EV71 and EV-D68 replication, commonly used for research on viral infection mechanisms.
Targets & IC50	RD cells:0.009 μM (EC50), H1-HeLa cells:14 nM (EC50), rhinovirus (HRV) 3C cysteine protease mimetic peptide:0.023 μM (EC50), Vero cells:0.419 μM (EC50), HeLa cells:0.27 μM (EC50)
In vitro	Methods: RD cells were incubated with gradient concentrations of Rupintrivir for 3–4 days. Results: Rupintrivir showed potent inhibition against EV-D68, RV-87, and EV-71, with EC₅₀ of 0.0022–0.0053 μM and EC₉₀ of 0.004 μM against EV-D68, demonstrating the strongest activity among ten tested compounds. [1] Methods: A fluorescence resonance energy transfer (FRET) assay was used. Gradient concentrations of Rupintrivir were co-incubated with purified DHAV 3C protease and fluorescent substrate for 2 hours. Results: It showed inhibitory activity against duck hepatitis A virus 3C protease. [2]
In vivo	Methods: Precision-cut lung slices were prepared from HDM-sensitized Balb/c mice, infected ex vivo with RV1b (10⁵ TCID₅₀/mL), and treated with 100 nM Rupintrivir for 48 hours. Results: Rupintrivir significantly inhibited RV-induced excessive secretion of IL-4 and IL-6 in the HDM-sensitized group without affecting interferon responses. [3]
Synonyms	Rupintrivirvr, AG-7088, AG7088

Chemical Properties

Molecular Weight	598.66
Formula	C₃₁H₃₉FN₄O₇
Cas No.	223537-30-2
Smiles	CCOC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@@H](CC(=O)[C@@H](NC(=O)c1cc(C)on1)C(C)C)Cc1ccc(F)cc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (421.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (3.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6704 mL	8.3520 mL	16.7040 mL	83.5199 mL
5 mM	0.3341 mL	1.6704 mL	3.3408 mL	16.7040 mL
10 mM	0.1670 mL	0.8352 mL	1.6704 mL	8.3520 mL
20 mM	0.0835 mL	0.4176 mL	0.8352 mL	4.1760 mL
50 mM	0.0334 mL	0.1670 mL	0.3341 mL	1.6704 mL
100 mM	0.0167 mL	0.0835 mL	0.1670 mL	0.8352 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc