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Rupintrivir

Name: Rupintrivir
Brand: TargetMol
SKU: T16809
Price: 118 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16809Cas No. 223537-30-2

Alias Rupintrivirvr, AG-7088, AG7088

Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.

Rupintrivir

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Purity: 99.35%

Catalog No. T16809Alias Rupintrivirvr, AG-7088, AG7088Cas No. 223537-30-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$118	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$419	In Stock	In Stock
25 mg	$737	In Stock	In Stock
50 mg	$977	-	In Stock
100 mg	$1,290	-	In Stock
1 mL x 10 mM (in DMSO)	$347	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.35%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS HNMR

Product Introduction

Bioactivity

Description	Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.
Targets&IC50	RD cells:0.009 μM (EC50), Vero cells:0.419 μM (EC50), H1-HeLa cells:14 nM (EC50), rhinovirus (HRV) 3C cysteine protease mimetic peptide:0.023 μM (EC50), HeLa cells:0.27 μM (EC50)
In vitro	In H1-HeLa and MRC-5 cell protection assays, Rupintrivir (AG7088) inhibited the replication of all HRV serotypes (48 of 48) tested with a mean 50% effective concentration (EC50) of 0.023 microM (range, 0.003 to 0.081 microM) and a mean EC90 of 0.082 microM (range, 0.018 to 0.261 microM) as well as that of related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11[1].
In vivo	PCLS from HDM-sensitized mice showed an attenuated antiviral response, but exaggerated IL-4, IL-6, and IL-10 secretion upon infection. Rupintrivir(AG7088) inhibited exaggerated pro-inflammatory cytokine IL-6 and TH-2 cytokine IL-4 in HDM-sensitized mice[2].
Synonyms	Rupintrivirvr, AG-7088, AG7088

Chemical Properties

Molecular Weight	598.66
Formula	C₃₁H₃₉FN₄O₇
Cas No.	223537-30-2
Smiles	CCOC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@@H](CC(=O)[C@@H](NC(=O)c1cc(C)on1)C(C)C)Cc1ccc(F)cc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 252.5 mg/mL (421.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (3.34 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6704 mL	8.3520 mL	16.7040 mL	83.5199 mL
5 mM	0.3341 mL	1.6704 mL	3.3408 mL	16.7040 mL
10 mM	0.1670 mL	0.8352 mL	1.6704 mL	8.3520 mL
20 mM	0.0835 mL	0.4176 mL	0.8352 mL	4.1760 mL
50 mM	0.0334 mL	0.1670 mL	0.3341 mL	1.6704 mL
100 mM	0.0167 mL	0.0835 mL	0.1670 mL	0.8352 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc