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Anti-HMGCR Antibody (4H804)
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Catalog No. TMAC-01982
Alias HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Anti-HMGCR Antibody (4H804) is a Rabbit antibody targeting HMGCR. Anti-HMGCR Antibody (4H804) can be used in WB,IP.
Anti-HMGCR Antibody (4H804)
Anti-HMGCR Antibody (4H804)
😃Good
Catalog No. TMAC-01982Alias HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Anti-HMGCR Antibody (4H804) is a Rabbit antibody targeting HMGCR. Anti-HMGCR Antibody (4H804) can be used in WB,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $298 | 7-10 days | |
| 100 μL | $496 | 7-10 days |
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-HMGCR Antibody (4H804) is a Rabbit antibody targeting HMGCR. Anti-HMGCR Antibody (4H804) can be used in WB,IP. |
| Synonyms | HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of HMGCR on Hela cells lysates using anti-HMGCR antibody at 1/1,000 dilution. |
| Application | |
| Recommended Dose | WB: 1:1000-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 97 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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