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Anti-HMGCR Antibody (4H804) (Synonyms: HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reducta...)

Catalog No. TMAC-01982 Copy Product Info
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Anti-HMGCR Antibody (4H804) is a Rabbit antibody targeting HMGCR. Anti-HMGCR Antibody (4H804) can be used in IP,WB.

Anti-HMGCR Antibody (4H804)

Copy Product Info
🥰Excellent
Catalog No. TMAC-01982
Synonyms HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Anti-HMGCR Antibody (4H804) is a Rabbit antibody targeting HMGCR. Anti-HMGCR Antibody (4H804) can be used in IP,WB.

Anti-HMGCR Antibody
(4H804)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2987-10 days7-10 days
100 μL$4967-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-HMGCR Antibody (4H804) is a Rabbit antibody targeting HMGCR. Anti-HMGCR Antibody (4H804) can be used in IP,WB.
SynonymsHMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Ig Type
IgG
Clone
4H804
Reactivity
Human,Mouse,Rat
Verified Activity
1. Western blot analysis of HMGCR on Hela cells lysates using anti-HMGCR antibody at 1/1,000 dilution.
verifiedActivity
Application
Recommended Dose
WB: 1:1000-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundThe human enzyme hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) limits the rate of cholesterol synthesis, a necessary process for cellular growth, in liver tissue. Phosphorylation of HMGCR inactivates the enzyme, which occurs via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from the product of the reductase reaction. Inhibitors of HMGCR (statins) exert inflammatory effects and decrease the frequency of cardiovascular events by lowering plasma cholesterol. Additionally, intermediate products along the pathway catalyzed by HMGCR, which modulate signal transducing proteins such as Ras, provide possible ties between HMGCR regulation and new chemotherapeutic methods.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 97 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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