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Nitroaspirin

Name: Nitroaspirin
Brand: TargetMol
SKU: T16328
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16328Cas No. 175033-36-0

Alias NCX 4016

Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin that inhibits cyclooxygenase. It induces cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells by down-regulating EGFR/PI3K/STAT3 signaling and modulating Bcl-2 family proteins. Additionally, Nitroaspirin possesses antithrombotic and antiplatelet properties and acts as a direct and irreversible inhibitor of COX-1.

Nitroaspirin

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Purity: 99.32%

Catalog No. T16328Alias NCX 4016Cas No. 175033-36-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$75	In Stock	In Stock
10 mg	$108	In Stock	In Stock
25 mg	$183	In Stock	In Stock
50 mg	$269	In Stock	In Stock
100 mg	$395	In Stock	In Stock
200 mg	$588	-	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.32%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Nitroaspirin AI Summary

Nitroaspirin exhibits a range of biological activities. It induces apoptosis in human HT29 cells with an EC50 of 1000 µM after 24 hours. Additionally, it demonstrates antiviral efficacy against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells by 3.08% and in VERO-6 cells by 0.23%, both at a concentration of 10 µM after 48 hours. The compound also shows a 7.181% inhibition of the SARS-CoV-2 3CL-Pro protease at a 20 µM concentration, measured by a FRET-based peptide substrate assay. Furthermore, Nitroaspirin exhibits significant inhibition of the HDAC6 enzyme, achieving a 48.08% inhibition with a commercial peptide substrate, though this effect is reduced to 1.86% when using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

NCX 4016

Chemical Properties

Molecular Weight	331.28
Formula	C₁₆H₁₃NO₇
Cas No.	175033-36-0
Smiles	O(C(C)=O)C1=C(C(OC2=CC(CON(=O)=O)=CC=C2)=O)C=CC=C1
Relative Density.	1.347 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (166.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 5 mg/mL (15.09 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0186 mL	15.0930 mL	30.1859 mL	150.9297 mL
5 mM	0.6037 mL	3.0186 mL	6.0372 mL	30.1859 mL
10 mM	0.3019 mL	1.5093 mL	3.0186 mL	15.0930 mL
20 mM	0.1509 mL	0.7546 mL	1.5093 mL	7.5465 mL
50 mM	0.0604 mL	0.3019 mL	0.6037 mL	3.0186 mL
100 mM	0.0302 mL	0.1509 mL	0.3019 mL	1.5093 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc