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LH846

Name: LH846
Brand: TargetMol
SKU: T1877
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T1877Cas No. 639052-78-1

Alias LH-846, LH 846

LH846 is a selective inhibitor of CK1δ with IC50 values of 290 nM for CK1δ, 1.3 μM for CK1ε, and 2.5 μM for CK1α, and exhibits no inhibitory activity at CK2.

LH846

🥰Excellent

Purity: 98.26%

Catalog No. T1877Alias LH-846, LH 846Cas No. 639052-78-1

LH846 is a selective inhibitor of CK1δ with IC50 values of 290 nM for CK1δ, 1.3 μM for CK1ε, and 2.5 μM for CK1α, and exhibits no inhibitory activity at CK2.

Pack Size	Price	Availability
5 mg	$58	In Stock
10 mg	$79	In Stock
25 mg	$148	In Stock
50 mg	$247	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock

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Batch Information

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Purity:98.26%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	LH846 is a selective inhibitor of CK1δ with IC50 values of 290 nM for CK1δ, 1.3 μM for CK1ε, and 2.5 μM for CK1α, and exhibits no inhibitory activity at CK2.
Targets&IC50	CK1δ:290 nM, CK1ε:1.3 μM, CK1α:2.5 μM
Synonyms	LH-846, LH 846

Chemical Properties

Molecular Weight	316.81
Formula	C₁₆H₁₃ClN₂OS
Cas No.	639052-78-1
Smiles	Cc1cc2sc(NC(=O)Cc3ccccc3)nc2cc1Cl
Relative Density.	1.387 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (173.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1565 mL	15.7823 mL	31.5647 mL	157.8233 mL
5 mM	0.6313 mL	3.1565 mL	6.3129 mL	31.5647 mL
10 mM	0.3156 mL	1.5782 mL	3.1565 mL	15.7823 mL
20 mM	0.1578 mL	0.7891 mL	1.5782 mL	7.8912 mL
50 mM	0.0631 mL	0.3156 mL	0.6313 mL	3.1565 mL
100 mM	0.0316 mL	0.1578 mL	0.3156 mL	1.5782 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc