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Zimberelimab (Synonyms: WBP-3055, WBP3055, GLS-010, GLS010, AB-122, AB122)
Catalog No. T76709 Copy Product Info
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Zimberelimab (GLS-010) is a humanized monoclonal antibody targeting PD-1, with antitumor activity. It blocks the interaction between PD-L1, PD-L2, and PD-1 on the cell surface, and is used in studies of cervical cancer and non-small cell lung cancer.
Zimberelimab
Copy Product Info🥰Excellent
Catalog No. T76709
Synonyms WBP-3055, WBP3055, GLS-010, GLS010, AB-122, AB122
Zimberelimab (GLS-010) is a humanized monoclonal antibody targeting PD-1, with antitumor activity. It blocks the interaction between PD-L1, PD-L2, and PD-1 on the cell surface, and is used in studies of cervical cancer and non-small cell lung cancer.
Zimberelimab
Cas No. 2259860-24-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | In Stock | In Stock | |
| 5 mg | $645 | In Stock | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,530 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.11% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Zimberelimab (GLS-010) is a humanized monoclonal antibody targeting PD-1, with antitumor activity. It blocks the interaction between PD-L1, PD-L2, and PD-1 on the cell surface, and is used in studies of cervical cancer and non-small cell lung cancer. |
| Targets&IC50 | PD-1 (human):210 pM (EC50) |
| In vitro | Zimberelimab is a fully human IgG4 anti-PD-1 monoclonal antibody with an EC50 of 210 pM for human PD-1. Zimberelimab can effectively block the binding of PD-L1 and PD-L2 to PD-1 on the cell surface in CHO-S cells, with IC50 values of 580 pM and 670 pM, respectively. [1] The equilibrium dissociation constant (KD) between Zimberelimab and PD-1 is 1.75×10-10 M. [2] |
| In vivo | Zimberelimab showed a statistically significant antitumor effect in the MC38 model of human PD-1 knock-in mice. [2] |
| Synonyms | WBP-3055, WBP3055, GLS-010, GLS010, AB-122, AB122 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | PDCD1/PD-1/CD279 |
| Molecular Weight | 146.54 kDa |
| Cas No. | 2259860-24-5 |
| Isotype | Human IgG4SP lambda |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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