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Zimberelimab
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Catalog No. T76709Cas No. 2259860-24-5
Alias WBP-3055, WBP3055, GLS-010, GLS010, AB-122, AB122
Zimberelimab (GLS-010) is a humanized monoclonal antibody targeting PD-1, with antitumor activity. It blocks the interaction between PD-L1, PD-L2, and PD-1 on the cell surface, and is used in studies of cervical cancer and non-small cell lung cancer.
Zimberelimab
Zimberelimab
😃Good
Catalog No. T76709Alias WBP-3055, WBP3055, GLS-010, GLS010, AB-122, AB122Cas No. 2259860-24-5
Zimberelimab (GLS-010) is a humanized monoclonal antibody targeting PD-1, with antitumor activity. It blocks the interaction between PD-L1, PD-L2, and PD-1 on the cell surface, and is used in studies of cervical cancer and non-small cell lung cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | In Stock | In Stock | |
| 5 mg | $645 | In Stock | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,530 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.11% (SEC-HPLC)
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| Description | Zimberelimab (GLS-010) is a humanized monoclonal antibody targeting PD-1, with antitumor activity. It blocks the interaction between PD-L1, PD-L2, and PD-1 on the cell surface, and is used in studies of cervical cancer and non-small cell lung cancer. |
| Targets&IC50 | PD-1 (human):210 pM (EC50) |
| In vitro | Zimberelimab is a fully human IgG4 anti-PD-1 monoclonal antibody with an EC50 of 210 pM for human PD-1. Zimberelimab can effectively block the binding of PD-L1 and PD-L2 to PD-1 on the cell surface in CHO-S cells, with IC50 values of 580 pM and 670 pM, respectively. [1] The equilibrium dissociation constant (KD) between Zimberelimab and PD-1 is 1.75×10-10 M. [2] |
| In vivo | Zimberelimab showed a statistically significant antitumor effect in the MC38 model of human PD-1 knock-in mice. [2] |
| Synonyms | WBP-3055, WBP3055, GLS-010, GLS010, AB-122, AB122 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | PDCD1/PD-1/CD279 |
| Molecular Weight | 146.54 kDa |
| Cas No. | 2259860-24-5 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG4SP lambda |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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