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Anti-Endoglin/CD105 Antibody-PE (4U724)
🥰Excellent
Catalog No. TMAY-03276P
Anti-Endoglin/CD105 Antibody-PE (4U724) is a PE-conjugated Rabbit antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody-PE (4U724) can be used in FCM.
Anti-Endoglin/CD105 Antibody-PE (4U724)
Anti-Endoglin/CD105 Antibody-PE (4U724)
🥰Excellent
Catalog No. TMAY-03276P
Anti-Endoglin/CD105 Antibody-PE (4U724) is a PE-conjugated Rabbit antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody-PE (4U724) can be used in FCM.
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Product Introduction
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Related Conjugates and Formulations
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Chemical Properties
| Description | Anti-Endoglin/CD105 Antibody-PE (4U724) is a PE-conjugated Rabbit antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody-PE (4U724) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4U724 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse ENG(CD105) expression on bEnd.3 cells. Cells were stained with PE-conjugated anti-Mouse ENG(CD105). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Endoglin / CD105 / ENG (rM Endoglin / CD105 / ENG; TMPY-01615; NP_031958.2; Met1-Gly580) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types. |
| Conjucates | PE |
| Others Formats | Unconjugated/APC/FITC |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Mouse Endoglin / CD105 / ENG Protein (TMPY-01615) |
| Antigen Species | Mouse |
| Biology Area | Hemangioblast Markers, Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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