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Nectin-2 Protein, Human, Recombinant (His)

Catalog No. TMPY-00747
Synonyms: PVRR2, Nectin-2, poliovirus receptor-related 2 (herpesvirus entry mediator B), CD112, HVEB, PRR2

Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Nectin-2 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
100 μg In stock $ 376.00
200 μg 5 days $ 665.00
500 μg 5 days $ 1,410.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information 1. Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD112 at 20 μg/ml (100 μl/well) can bind biotinylated DNAM1 with a linear range of 0.078-2.5 μg/ml. 2. Using the Octet RED System, the affinity constant (Kd) of Anti-CD112 Antibody   bound to Nectin-2 Protein, Human, Recombinant (His Tag)   was 34.4 nM.

Description Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2.
Species Human
Expression System HEK293 Cells
Tag C-His
Accession Number Q92692-2
Synonyms PVRR2, Nectin-2, poliovirus receptor-related 2 (herpesvirus entry mediator B), CD112, HVEB, PRR2
Construction extracellular domain (Met 1-Leu 360) of Human CD112 (NP_002847.1)
Protein Purity ≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

Molecular Weight 36.2 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

References and Literature

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Keywords

Nectin-2 Protein, Human, Recombinant (His) herpesvirus entry mediator B CD-112 PVRR2 Nectin-2 poliovirus receptor-related 2 poliovirus receptor-related 2 (herpesvirus entry mediator B) PRR-2 PRR 2 PVRR-2 CD112 HVEB PVRR 2 PRR2 CD 112 recombinant recombinant-proteins proteins protein

 

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