FKK [N-(heptyloxycarbonylaminosulfonyl)-2-aminobenzamide] is an indazole derivative and a novel bronchodilator.

FKK, an indazole derivative and novel bronchodilator, induces direct vasodilation in the coronary, mesenteric, and femoral vessels without affecting the renal vasculature. Notably, at a dosage of 30 mg/kg, intradermally (i.d.), FKK effectively causes bronchodilation without significantly impacting the cardiovascular system, unlike aminophylline at the same dosage and administration route. Additionally, FKK administered intravenously (i.v.) at dosages ranging from 0.1 to 3.0 mg/kg modestly elevates respiratory frequency, maximizes the rate of left ventricular (LV) pressure rise (dp/dt max), and enhances myocardial contractile strength. This administration also leads to a transient increase followed by a decrease in both systemic blood pressure and LV systolic pressure.