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SOS1-IN-22
Catalog No. T213162 Copy Product Info
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SOS1-IN-22 is an inhibitor of the non-heptakinase homologue (SOS1). It effectively prevents the formation of the KRAS-G12C/SOS1 complex with an IC50 value of 40.28 nM. Additionally, SOS1-IN-22 reduces the phosphorylation levels of ERK. This compound is applicable in cancer research, including studies on pancreatic and appendiceal cancers.
SOS1-IN-22
Copy Product Info🥰Excellent
Catalog No. T213162
SOS1-IN-22 is an inhibitor of the non-heptakinase homologue (SOS1). It effectively prevents the formation of the KRAS-G12C/SOS1 complex with an IC50 value of 40.28 nM. Additionally, SOS1-IN-22 reduces the phosphorylation levels of ERK. This compound is applicable in cancer research, including studies on pancreatic and appendiceal cancers.
SOS1-IN-22
Cas No. 3092445-74-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | SOS1-IN-22 is an inhibitor of the non-heptakinase homologue (SOS1). It effectively prevents the formation of the KRAS-G12C/SOS1 complex with an IC50 value of 40.28 nM. Additionally, SOS1-IN-22 reduces the phosphorylation levels of ERK. This compound is applicable in cancer research, including studies on pancreatic and appendiceal cancers. |
| In vitro | SOS1-IN-22 (Compound A15f) demonstrates proliferation inhibitory activity in K562 cells with an IC50 value of 1.03 μM. It inhibits the formation of the KRAS-G12C/SOS1 complex at concentrations of 0-10000 nM. Additionally, SOS1-IN-22 reduces pERK levels in K562 cells in a dose-dependent manner at 0-300 nM for 2 hours. When combined with AMG510 (20 nM), SOS1-IN-22 significantly enhances the inhibition of pERK expression in MIAPaCa-2 cells at concentrations of 1-10 μM over 2 hours. Furthermore, SOS1-IN-22 shows no notable cytotoxicity in HL-7702 and 5k cells at doses ranging from 0.0001 to 10 μM over 72 hours. |
| Molecular Weight | 462.52 |
| Formula | C24H29F3N4O2 |
| Cas No. | 3092445-74-1 |
| Smiles | N([C@H](C)C1=C(F)C(C(F)F)=CC=C1)C2=C3C(C(C)(C)C(=O)N(C3)C4CCOCC4)=NC(C)=N2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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