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Iniparib
🥰Excellent
Catalog No. T6224Cas No. 160003-66-7
Alias NSC-746045, IND-71677, BSI-201
Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
Iniparib
🥰Excellent
Purity: 98.93%
Catalog No. T6224Alias NSC-746045, IND-71677, BSI-201Cas No. 160003-66-7
Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $46 | In Stock | |
| 10 mg | $70 | In Stock | |
| 25 mg | $128 | In Stock | |
| 50 mg | $241 | In Stock | |
| 100 mg | $378 | In Stock | |
| 200 mg | $600 | In Stock | |
| 500 mg | $959 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:98.93%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC). |
| In vivo | In 855-2 cells, the combination of BSI-201 (120 μM) and buthionine sulfoximine induced cell death up to 95%, which was similar to the effect on other human tumor cells. In E-ras 20 cells, BSI-201 inhibited cell growth, and its effect was enhanced 20-fold when combined with buthionine sulfoximine. BSI-201 (100 μM) inhibited the repair of ionizing radiation-induced single-strand breaks (SSBs) in human lymphocyte cell lines. |
| Cell Research | Cells are exposed to various concentrations of BSI-201 for 5, and 9 days in the presence or absence of buthionine sulfoxamide (BSO). After treatment, cell proliferation is measured by CellTiter-Glo assay.(Only for Reference) |
| Synonyms | NSC-746045, IND-71677, BSI-201 |
| Molecular Weight | 292.03 |
| Formula | C7H5IN2O3 |
| Cas No. | 160003-66-7 |
| Smiles | N(=O)(=O)C1=CC(C(N)=O)=CC=C1I |
| Relative Density. | 2.055 g/cm3 (Predicted) |
| Color | Red |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 14.6 mg/mL (49.99 mM), Sonication is recommended. DMSO: 85 mg/mL (291.07 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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