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Idoxifene

Name: Idoxifene
Brand: TargetMol
SKU: T14883
Price: 68 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14883Cas No. 116057-75-1

Alias CB7432

Idoxifene (CB7432) is a selective and tissue-specific estrogen receptor modulator (SERM) that reduces collagen and malondialdehyde (MDA) levels in rat liver, exhibiting anti-fibrotic effects.

Idoxifene

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Purity: 100%

Catalog No. T14883Alias CB7432Cas No. 116057-75-1

Idoxifene (CB7432) is a selective and tissue-specific estrogen receptor modulator (SERM) that reduces collagen and malondialdehyde (MDA) levels in rat liver, exhibiting anti-fibrotic effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$68	-	In Stock
5 mg	$163	-	In Stock
10 mg	$289	-	In Stock
25 mg	$619	-	In Stock
50 mg	$1,070	-	In Stock
100 mg	$1,820	-	In Stock
1 mL x 10 mM (in DMSO)	$189	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:100%

Appearance:Solid

Color:Gray

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Idoxifene (CB7432) is a selective and tissue-specific estrogen receptor modulator (SERM) that reduces collagen and malondialdehyde (MDA) levels in rat liver, exhibiting anti-fibrotic effects.
In vitro	In vascular smooth muscle cells, Idoxifene inhibits Angiotensin II-induced reactive oxygen species (ROS) production [1]. In cultured activated hepatic stellate cells, Idoxifene dose-dependently inhibits activation and proliferation while time-dependently inducing apoptosis [1]. Idoxifene acts as an estrogen receptor agonist on osteoblasts in bone and exhibits weak agonist activity in human endometrial cells. Idoxifene and estradiol (E2) protect hepatocytes from inflammatory cell damage by inhibiting NF-κB activation [2].
In vivo	Following DMN treatment, rats administered daily intraperitoneal estradiol (0.5 mg/kg) alongside Idoxifene (0.1 and 0.5 mg/kg; oral) for 3 days exhibited dose-dependent reductions in liver collagen and malondialdehyde (MDA) levels, demonstrating antifibrotic effects [2].
Synonyms	CB7432

Chemical Properties

Molecular Weight	523.45
Formula	C₂₈H₃₀INO
Cas No.	116057-75-1
Smiles	C(=C(/CC)\C1=CC=CC=C1)(\C2=CC=C(OCCN3CCCC3)C=C2)/C4=CC=C(I)C=C4
Relative Density.	1.329g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (76.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9104 mL	9.5520 mL	19.1040 mL	95.5201 mL
5 mM	0.3821 mL	1.9104 mL	3.8208 mL	19.1040 mL
10 mM	0.1910 mL	0.9552 mL	1.9104 mL	9.5520 mL
20 mM	0.0955 mL	0.4776 mL	0.9552 mL	4.7760 mL
50 mM	0.0382 mL	0.1910 mL	0.3821 mL	1.9104 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc