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IDO

Indoleamine-pyrrole 2,3-dioxygenase (IDO) is a heme-containing enzyme physiologically expressed in several tissues and cells, such as the small intestine, lungs, female genital tract or placenta.IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway. IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.

Epacadostat
T35481204669-58-8
Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.
  • $39
In Stock
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Linrodostat
T45321923833-60-6
Linrodostat (BMS-986205) is a selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1).
  • $52
In Stock
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β-Lapachone
T64074707-32-8
β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
  • $40
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PF-06840003
T4307198474-05-4
PF-06840003 (EOS200271) is a specific and orally active IDO-1 inhibitor.
  • $38
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IDO-IN-12
T116151888341-29-4In house
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
  • $81
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LY3381916
T119012166616-75-5
LY3381916 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
  • $34
In Stock
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BMS-986242
T91641923844-48-7
BMS-986242 is an orally active, potent, and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, suitable for cancer research.
  • $86
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GNF-PF-3777
T1019977603-42-0
GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2) with a Ki of 0.97 μM.
  • $30
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IDO1-IN-1
T20513615-21-4
IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
  • $29
In Stock
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IDO5L
T2647914471-09-3
IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
  • $43
In Stock
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IDO-IN-13
T116162291164-02-6
IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
  • $53
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Kushenol E
T821499119-72-9
Kushenol E (Flemiphilippinin D) is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has anti-tumor activity.
  • $261
7-10 days
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IACS-8968 R-enantiomer
T116272239305-67-8
IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
  • $1,520
6-8 weeks
Size
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IDO-IN-11
T116141888378-32-2
IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 values of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
  • $1,980
6-8 weeks
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IDO-IN-6
T116201402837-76-6
IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
  • $1,190
6-8 weeks
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IDO-IN-9
T116221888378-12-8
IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50 values of 0.011 μM for kinase and 0.0018 μM for Hela cells.
  • $1,820
8-10 weeks
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IDO1-IN-2
T116242346614-58-0
IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
  • $1,520
6-8 weeks
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IACS-8968 S-enantiomer
T116282239305-70-3
IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
  • $1,520
6-8 weeks
Size
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IDO-IN-3
T116172070018-30-1
IDO-IN-3 is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO), with an IC50 value of 290 nM.
  • $227
6-8 weeks
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IDO-IN-8
T116211402837-77-7
IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
  • $1,190
6-8 weeks
Size
QTY
IACS-8968
T116262144425-14-7
IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
  • $1,670
6-8 weeks
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IDO-IN-5
T116191402837-79-9
IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
  • $1,190
6-8 weeks
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