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Anti-DMAP1 Antibody (3C360)
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Catalog No. TMAB-05199 Copy Product Info
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Anti-DMAP1 Antibody (3C360) is a Rabbit antibody targeting DMAP1. Anti-DMAP1 Antibody (3C360) can be used in FCM, ICC/IF, WB.
Anti-DMAP1 Antibody
(3C360)
(3C360)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 μL | $149 | 7-10 days | 7-10 days | |
| 50 μL | $263 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-DMAP1 Antibody (3C360) is a Rabbit antibody targeting DMAP1. Anti-DMAP1 Antibody (3C360) can be used in FCM, ICC/IF, WB. |
| Ig Type | IgG |
| Clone | 3C360 |
| Reactivity | Human,Mouse (predicted:Rat) |
| Application | |
| Recommended Dose | FCM=1:50-100; ICC/IF=1:50-200; WB=1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. |
| Immunogen | A synthesized peptide: human DMAP1 |
| Antigen Species | Human |
| Gene Name | DMAP1 |
| Gene ID | |
| Protein Name | DNA methyltransferase 1-associated protein 1 |
| Uniprot ID | |
| Function | DMAP1 is involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. |
| Molecular Weight | Theoretical: 53 kDa. Actual: 60 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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