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Anti-Phospho-BACE1 (Ser498) Polyclonal Antibody 2

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Catalog No. TMAB-10365

Anti-Phospho-BACE1 (Ser498) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-BACE1 (Ser498). Anti-Phospho-BACE1 (Ser498) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.

Anti-Phospho-BACE1 (Ser498) Polyclonal Antibody 2

Anti-Phospho-BACE1 (Ser498) Polyclonal Antibody 2

😃Good
Catalog No. TMAB-10365
Anti-Phospho-BACE1 (Ser498) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-BACE1 (Ser498). Anti-Phospho-BACE1 (Ser498) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2227-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5287-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-Phospho-BACE1 (Ser498) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-BACE1 (Ser498). Anti-Phospho-BACE1 (Ser498) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
Reactivity
Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit)
Application
Recommended Dose
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationMembrane.
Tissue SpecificityExpressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
ConstructionHybridoma Polyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research Backgroundbs-0164P is one synthetic peptide derived from human BACE1. Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein(APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
Antigen Details
Immunogen
KLH conjugated Synthesised phosphopeptide: human BACE1 around the phosphorylation site of Ser498
Antigen Species
Human
Gene Name
BACE1
Gene ID
Protein Name
beta-secretase 1
Uniprot ID
Function
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
Chemical Properties
Molecular WeightTheoretical: 51 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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