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IR415

Name: IR415
Brand: TargetMol
SKU: T11669
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11669Cas No. 452967-14-5

IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity.

IR415

🥰Excellent

Purity: 99.85%

Catalog No. T11669Cas No. 452967-14-5

Pack Size	Price	Availability
5 mg	$38	In Stock
10 mg	$68	In Stock
25 mg	$137	In Stock
50 mg	$238	In Stock
100 mg	$353	In Stock
200 mg	$493	In Stock
1 mL x 10 mM (in DMSO)	$42	In Stock

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Batch Information

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Purity:99.85%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 is a potent anti-HBV agent and inhibits HBV replication by blocking the HBx activity.
Targets&IC50	HBx:2 nM(Kd)
In vitro	IR415, at concentrations ranging from 50 to 200 μM, exhibits a dose-dependent inhibition of the Hepatitis B virus X protein (HBx), achieving its minimal effective concentration at 50 μM in the HepG2/GFP-shRNA line expressing HBx. HBx is identified as a suppressor of the host's defense mechanisms, specifically involved in the RNAi-based silencing of viral genes.

Chemical Properties

Molecular Weight	296.34
Formula	C₁₃H₁₄F₂N₄S
Cas No.	452967-14-5
Smiles	Fc1ccc(NC(=S)NCCCn2ccnc2)c(F)c1
Relative Density.	1.32 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (421.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3745 mL	16.8725 mL	33.7450 mL	168.7251 mL
5 mM	0.6749 mL	3.3745 mL	6.7490 mL	33.7450 mL
10 mM	0.3375 mL	1.6873 mL	3.3745 mL	16.8725 mL
20 mM	0.1687 mL	0.8436 mL	1.6873 mL	8.4363 mL
50 mM	0.0675 mL	0.3375 mL	0.6749 mL	3.3745 mL
100 mM	0.0337 mL	0.1687 mL	0.3375 mL	1.6873 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc