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Cichoric Acid
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Catalog No. TL0006Cas No. 6537-80-0
Alias Dicaffeoyltartaric acid, Chicoric Acid
Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and independent.
Cichoric Acid
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Purity: 98.77%
Catalog No. TL0006Alias Dicaffeoyltartaric acid, Chicoric AcidCas No. 6537-80-0
Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and independent.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $35 | In Stock | In Stock | |
| 10 mg | $57 | In Stock | In Stock | |
| 25 mg | $117 | In Stock | In Stock | |
| 50 mg | $198 | In Stock | In Stock | |
| 100 mg | $297 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:98.77%
Appearance:Solid
Color:White
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Product Introduction
Cichoric Acid AI Summary
Cichoric Acid exhibits inhibitory activity against HIV-1 integrase with IC50 values ranging from 0.1 to 24,900 nM, indicating variability across different assays. It has a Kd value of 3000 nM and demonstrates cytoprotection in CEM-SS cells with an IC50 of 20,100 nM. Against MT4 cells, it shows an EC50 of 12,700 nM for antiviral activity and a CC50 of 115,000 nM for cytotoxicity. The compound selectively inhibits HIV-1 integrase over reverse transcriptase with a fold change of 10. Additionally, it displays cytotoxic effects against MT2 cells with an LD50 of 700 µM. Cichoric Acid also inhibits SARS-CoV-2 3CL-Pro and MPro enzymes and shows diverse bioactivities such as inducing insulin secretion, inhibiting HIV-1 subtype C integrase, and blocking the activity of Yersinia enterocolitica YopH..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cichoric Acid (Dicaffeoyltartaric acid) is a potent inhibitor of human immunodeficiency virus type-1 (HIV-1) integrase and the replication in tissues. It also a class of cannabinomimetics with CB2 receptor-dependent and independent. |
| Targets&IC50 | HIV-1 integrase:0.8 μM |
| Synonyms | Dicaffeoyltartaric acid, Chicoric Acid |
| Molecular Weight | 474.37 |
| Formula | C22H18O12 |
| Cas No. | 6537-80-0 |
| Smiles | [C@H]([C@@H](OC(C=CC1=CC(O)=C(O)C=C1)=O)C(O)=O)(OC(C=CC2=CC(O)=C(O)C=C2)=O)C(O)=O |
| Relative Density. | 1.641 g/cm3 (Predicted) |
| Storage | store at low temperature,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 5 mg/mL (10.54 mM), Sonication is recommended.  DMSO: 347 mg/mL (731.5 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 50% PEG300+50% Saline: 10 mg/mL (21.08 mM) Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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