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(Z)-Leukadherin-1
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Catalog No. T13379Cas No. 2055362-72-4
Alias ADH-503 free base
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
(Z)-Leukadherin-1
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Purity: 99.23%
Catalog No. T13379Alias ADH-503 free baseCas No. 2055362-72-4
(Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | - | In Stock | |
| 5 mg | $45 | - | In Stock | |
| 10 mg | $62 | - | In Stock | |
| 25 mg | $100 | - | In Stock | |
| 50 mg | $145 | - | In Stock | |
| 100 mg | $212 | - | In Stock | |
| 200 mg | $313 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.23%
Appearance:Solid
Color:Red
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (Z)-Leukadherin-1 (ADH-503 free base) is an allosteric agonist of CD11b. |
| In vitro | (Z)-Leukadherin-1 (4 μM) treatment reduces the numbers of total tumor-infiltrating CD11b+ cells and subsets of CD11b+ monocytes, eosinophils, granulocytes, and macrophages. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses[1]. |
| In vivo | (Z)-Leukadherin-1 shows a mean half-life of 4.68 and 3.95 h, a maximum concentration of 1716 and 2594 ng/ml and AUC(0-t) in the plasma of 6950 and 13962 ng·h/ml at 30 and 100 mg/kg dosing, respectively. In KPC mice, (Z)-Leukadherin-1 (30, 60, or 120 mg/kg; gavage) delayes tumor progression and leads to a significantly decreased tumor burden in time-point analysis and improved overall survival[1]. |
| Synonyms | ADH-503 free base |
| Molecular Weight | 421.49 |
| Formula | C22H15NO4S2 |
| Cas No. | 2055362-72-4 |
| Smiles | C(\C=1OC(=CC1)C2=CC=C(C(O)=O)C=C2)=C\3/C(=O)N(CC4=CC=CC=C4)C(=S)S3 |
| Relative Density. | 1.50 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (9.49 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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