EMD-C02602

Name: EMD-C02602
Brand: TargetMol
SKU: T213164
Rating: 4.5 (1 reviews)

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EMD-C02602 is a GCN2 inhibitor with IC50 values of 0.023 μM for GCN2, 4.52 μM for PERK, >10 μM for HRl, and 0.048 μM for PKR.

EMD-C02602

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For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

EMD-C02602 is a GCN2 inhibitor with IC50 values of 0.023 μM for GCN2, 4.52 μM for PERK, >10 μM for HRl, and 0.048 μM for PKR.

In vitro

EMD-C02602 exhibits a U-shaped activity response in MOLM-16 cells over a range of 0-10 μM for 72 hours, with the most significant reduction in cell viability at moderate concentrations (around 0.05 μM) and reduced inhibition at both lower and higher concentrations. Additionally, EMD-C02602 at concentrations between 0.05-0.12 μM for 8 hours increases ATF4 expression in these cells， and at concentrations of 0.5-1.1 μM for 8 hours, it enhances p-GCN2 expression without affecting GCN2 expression.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.