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Encequidar mesylate

Name: Encequidar mesylate
Brand: TargetMol
SKU: T11578L
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: HM30181A mesylate, HM30181 mesylate) Copy Product Info

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Synonyms: HM30181A mesylate, HM30181 mesylate

Catalog No. T11578L Copy Product Info

Purity: 99.84%

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Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.

Cas No. 849675-87-2

Pack Size	Price	USA Stock	Global Stock
2 mg	$35	In Stock	In Stock
5 mg	$56	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$157	In Stock	In Stock
50 mg	$263	In Stock	In Stock
100 mg	$413	In Stock	In Stock
500 mg	$939	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.84%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
In vitro	Administration of Encequidar at concentrations of 0.1 or 1 nM resulted in a reduction of cell survival by 20% and 42% upon exposure to 100 nM and 1000 nM of NSC 125973, respectively [2].
In vivo	When administered simultaneously, Encequidar demonstrates increased plasma concentrations with the microcapsule formulation compared to the powder, showing notable differences from 1 to 2 hours. The microcapsule formulation achieves a 1.7-fold quicker Tmax and a 1.6-fold greater AUC value than the powder (2.5±0.6 vs. 4.3±0.9 hours; 107.7±20.1 vs. 64.3±18.0 h ng/mL), indicating faster and more efficient absorption. This enhanced absorption of Encequidar in microcapsule format is likely attributed to its improved aqueous solubility and dissolution rates, facilitated by the conversion from crystalline to amorphous form and the reduction in particle size [1].
Synonyms	HM30181A mesylate, HM30181 mesylate

Chemical Properties

Molecular Weight	784.83
Formula	C₃₉H₄₀N₆O₁₀S
Cas No.	849675-87-2
Smiles	CS(O)(=O)=O.COc1cc2CCN(CCc3ccc(cc3)-n3nnc(n3)-c3cc(OC)c(OC)cc3NC(=O)c3cc(=O)c4ccccc4o3)Cc2cc1OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (79.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 6.25 mg/mL (7.96 mM), Suspension.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2742 mL	6.3708 mL	12.7416 mL	63.7081 mL
5 mM	0.2548 mL	1.2742 mL	2.5483 mL	12.7416 mL
10 mM	0.1274 mL	0.6371 mL	1.2742 mL	6.3708 mL
20 mM	0.0637 mL	0.3185 mL	0.6371 mL	3.1854 mL
50 mM	0.0255 mL	0.1274 mL	0.2548 mL	1.2742 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Encequidar mesylate chemical structure | Encequidar mesylate in vivo | Encequidar mesylate in vitro | Encequidar mesylate formula | Encequidar mesylate molecular weight