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Anti-Phospho-CRK (Tyr221) Antibody (7E679) is a Rabbit antibody targeting Phospho-CRK (Tyr221). Anti-Phospho-CRK (Tyr221) Antibody (7E679) can be used in ICC/IF, WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $369 | 7-10 days | 7-10 days | |
| 100 μL | $677 | 7-10 days | 7-10 days |
| Description | Anti-Phospho-CRK (Tyr221) Antibody (7E679) is a Rabbit antibody targeting Phospho-CRK (Tyr221). Anti-Phospho-CRK (Tyr221) Antibody (7E679) can be used in ICC/IF, WB. |
| Synonyms | Proto-oncogene c-Crk, p-CRK (Y221), p-CRK (Tyr221), CRKII, CRK (p-Y221), CRK (p-Tyr221), CRK, avian sarcoma virus CT10 (v-crk) oncogene homolog, Adapter molecule crk |
| Ig Type | IgG |
| Clone | 7E679 |
| Reactivity | Human |
| Specificity | Phospho-CRK (Tyr221) |
| Verified Activity | Western blot analysis of Phospho-CrkII (Tyr221) expression in (1) K562 cell lysate treated with AP; (2) K562 cell lysate. |
| Application | |
| Recommended Dose | ICC/IF: 1:50-1:200; WB: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Supplied in 10 mM phosphate buffered saline, pH 7.4, 150 mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| Research Background | The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. |
| Conjucates | Unconjugated |
| Immunogen | A synthesized peptide: human CRK around the phosphorylation site of Y221 |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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