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Omarigliptin

🥰Excellent

Catalog No. T2316Cas No. 1226781-44-7

Alias MK-3102

Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. [3]

Omarigliptin

🥰Excellent

Purity: 99.77%

Catalog No. T2316Alias MK-3102Cas No. 1226781-44-7

Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. [3]

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
2 mg	$48	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$126	In Stock	In Stock
25 mg	$223	In Stock	In Stock
50 mg	$369	In Stock	In Stock
100 mg	$531	In Stock	In Stock
500 mg	$1,180	In Stock	-
1 mL x 10 mM (in DMSO)	$140	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.77%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. [3]
Targets&IC50	DPP4:1.6 nM
In vitro	METHODS: HrGECs cells were stimulated with 0, 1, 2, 10, 20, 100 and 200 μM Omarigliptin for 24 hours and cell viability was observed. RESULTS When the concentration of Omarigliptin was 100 and 200 μM, the viability of HrGECs cells decreased significantly. [2]
In vivo	METHODS: A diabetic mouse model was established by treating with streptozotocin (STZ). Omarigliptin (2.5, 5 mg/kg, oral) was used to investigate the effects of Omarigliptin on glucose and insulin levels, cognitive dysfunction, oxidative stress, SIRT3 and FOXO3a expression, and NAD/NADH activity in STZ-induced diabetic mice. RESULTS Omarigliptin can significantly reduce blood glucose in STZ-induced diabetic mice, accompanied by increased serum insulin levels; Omarigliptin improves cognitive dysfunction in STZ-induced diabetic mice; Omarigliptin treatment rescues GSH in the hippocampus in a dose-dependent manner; Omarigliptin induces increased SIRT3 expression and prevents FOXO3a acetylation. [1]
Synonyms	MK-3102

Chemical Properties

Molecular Weight	398.43
Formula	C₁₇H₂₀F₂N₄O₃S
Cas No.	1226781-44-7
Smiles	CS(=O)(=O)n1cc2CN(Cc2n1)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F
Relative Density.	1.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (125.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.02 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5099 mL	12.5493 mL	25.0985 mL	125.4926 mL
5 mM	0.5020 mL	2.5099 mL	5.0197 mL	25.0985 mL
10 mM	0.2510 mL	1.2549 mL	2.5099 mL	12.5493 mL
20 mM	0.1255 mL	0.6275 mL	1.2549 mL	6.2746 mL
50 mM	0.0502 mL	0.2510 mL	0.5020 mL	2.5099 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2549 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc