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Omarigliptin
🥰Excellent
Catalog No. T2316Cas No. 1226781-44-7
Alias MK-3102
Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. [3]
Omarigliptin
🥰Excellent
Purity: 99.77%
Catalog No. T2316Alias MK-3102Cas No. 1226781-44-7
Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. [3]
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $34 | In Stock | In Stock | |
| 2 mg | $48 | In Stock | In Stock | |
| 5 mg | $77 | In Stock | In Stock | |
| 10 mg | $126 | In Stock | In Stock | |
| 25 mg | $223 | In Stock | In Stock | |
| 50 mg | $369 | In Stock | In Stock | |
| 100 mg | $531 | In Stock | In Stock | |
| 500 mg | $1,180 | In Stock | - | |
| 1 mL x 10 mM (in DMSO) | $140 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.77%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Omarigliptin is a potent and selective oral dipeptidyl peptidase 4 (DPP4) inhibitor with IC50 value of 1.6 nM. [3] |
| Targets&IC50 | DPP4:1.6 nM |
| In vitro | METHODS: HrGECs cells were stimulated with 0, 1, 2, 10, 20, 100 and 200 μM Omarigliptin for 24 hours and cell viability was observed. RESULTS When the concentration of Omarigliptin was 100 and 200 μM, the viability of HrGECs cells decreased significantly. [2] |
| In vivo | METHODS: A diabetic mouse model was established by treating with streptozotocin (STZ). Omarigliptin (2.5, 5 mg/kg, oral) was used to investigate the effects of Omarigliptin on glucose and insulin levels, cognitive dysfunction, oxidative stress, SIRT3 and FOXO3a expression, and NAD/NADH activity in STZ-induced diabetic mice. RESULTS Omarigliptin can significantly reduce blood glucose in STZ-induced diabetic mice, accompanied by increased serum insulin levels; Omarigliptin improves cognitive dysfunction in STZ-induced diabetic mice; Omarigliptin treatment rescues GSH in the hippocampus in a dose-dependent manner; Omarigliptin induces increased SIRT3 expression and prevents FOXO3a acetylation. [1] |
| Synonyms | MK-3102 |
| Molecular Weight | 398.43 |
| Formula | C17H20F2N4O3S |
| Cas No. | 1226781-44-7 |
| Smiles | CS(=O)(=O)n1cc2CN(Cc2n1)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F |
| Relative Density. | 1.61 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (125.49 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.02 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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