Shopping Cart

Your shopping cart is currently empty

AWL-II-38.3

Name: AWL-II-38.3
Brand: TargetMol
SKU: T38511
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T38511Cas No. 1135205-94-5

AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3 but no significant cellular activity against Src family kinases or b-raf.

AWL-II-38.3

Copy Product Info

😃Good

Purity: 99.57%

Catalog No. T38511Cas No. 1135205-94-5

AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3 but no significant cellular activity against Src family kinases or b-raf.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$74	In Stock	In Stock
5 mg	$178	In Stock	In Stock
10 mg	$278	In Stock	In Stock
25 mg	$572	In Stock	In Stock
50 mg	$822	In Stock	In Stock
100 mg	$1,130	-	In Stock
500 mg	$2,280	-	In Stock
1 mL x 10 mM (in DMSO)	$186	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.57%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3 but no significant cellular activity against Src family kinases or b-raf.

In vitro

The structure of AWL-II-38.3 fits into the ATP-binding and substrate-binding pockets of LIMK2 and LIMK1[1]；ALW-II-38.3 forms four direct hydrogen bonds between the ATP-binding cleft of EphA3: the first between the inhibitor oxazole N and the backbone NH of the hinge residue Met702, and the second between the oxazole amide NH and the gatekeeper Thr699 between the side chain hydroxyl group, the third between the benzamide carbonyl oxygen and the main chain NH of Asp764 of the "DFG-motif", the fourth between the inhibitor benzamide NH and the side chain carboxylate necessary for catalysis Glu670 is located in the αC-helix.[2]

Chemical Properties

Molecular Weight	469.42
Formula	C₂₃H₁₈F₃N₅O₃
Cas No.	1135205-94-5
Smiles	Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(NC(=O)c2ccno2)c1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (170.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1303 mL	10.6514 mL	21.3029 mL	106.5144 mL
5 mM	0.4261 mL	2.1303 mL	4.2606 mL	21.3029 mL
10 mM	0.2130 mL	1.0651 mL	2.1303 mL	10.6514 mL
20 mM	0.1065 mL	0.5326 mL	1.0651 mL	5.3257 mL
50 mM	0.0426 mL	0.2130 mL	0.4261 mL	2.1303 mL
100 mM	0.0213 mL	0.1065 mL	0.2130 mL	1.0651 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc