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AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3 but no significant cellular activity against Src family kinases or b-raf.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $74 | In Stock | |
5 mg | $178 | In Stock | |
10 mg | $278 | In Stock | |
25 mg | $572 | In Stock | |
50 mg | $822 | In Stock | |
100 mg | $1,130 | In Stock | |
500 mg | $2,280 | In Stock | |
1 mL x 10 mM (in DMSO) | $186 | In Stock |
Description | AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3 but no significant cellular activity against Src family kinases or b-raf. |
In vitro | The structure of AWL-II-38.3 fits into the ATP-binding and substrate-binding pockets of LIMK2 and LIMK1[1];ALW-II-38.3 forms four direct hydrogen bonds between the ATP-binding cleft of EphA3: the first between the inhibitor oxazole N and the backbone NH of the hinge residue Met702, and the second between the oxazole amide NH and the gatekeeper Thr699 between the side chain hydroxyl group, the third between the benzamide carbonyl oxygen and the main chain NH of Asp764 of the "DFG-motif", the fourth between the inhibitor benzamide NH and the side chain carboxylate necessary for catalysis Glu670 is located in the αC-helix.[2] |
Molecular Weight | 469.42 |
Formula | C23H18F3N5O3 |
Cas No. | 1135205-94-5 |
Smiles | Cc1cn(cn1)-c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(C)c(NC(=O)c2ccno2)c1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (95.86 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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