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AWL-II-38.3

Catalog No. T38511 CAS 1135205-94-5

AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf [1] [2].

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AWL-II-38.3, CAS 1135205-94-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf [1] [2].
In vitro	AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets [2] .

Molecular Weight	469.424
Formula	C23H18F3N5O3
CAS No.	1135205-94-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 65 mg/mL (138.47 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. 2. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.

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Keywords

AWL-II-38.3 1135205-94-5 蛋白酪氨酸激酶 Ephrin Receptor inhibit AWL II 38.3 LIMK1 Inhibitor LIMK2 EphA3 ATP AWLII38.3 inhibitor

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