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ML365
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Catalog No. T4316Cas No. 947914-18-3
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).
ML365
Copy Product Info🥰Excellent
Purity: 98.78%
Catalog No. T4316Cas No. 947914-18-3
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $44 | In Stock | In Stock | |
| 10 mg | $73 | In Stock | In Stock | |
| 25 mg | $135 | In Stock | In Stock | |
| 50 mg | $218 | In Stock | In Stock | |
| 100 mg | $347 | In Stock | - | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.78%
Appearance:Solid
Color:White
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Product Introduction
ML365 AI Summary
ML365 exhibits antagonist activity at rat mGluR5 receptors expressed in human HEK293A cells, inhibiting glutamate-induced calcium flux with an IC50 of 1350 nM. It is a potent and selective inhibitor of the two-pore domain potassium channel TASK1 (KCNK3), with IC50 values ranging from 4 nM to 12 nM in various assays, and it demonstrates selectivity against TASK3 (KCNK9) with IC50 values between 260 nM and 390 nM. The compound shows a high inhibition rate of 96.6% at 3 μM on TASK-1 channels, and minimal activity against KCNQ2, human ERG, and Kir2.1 channels. ML365 also exhibits antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in Caco-2 and VERO-6 cells with inhibition rates of 72.51% and 4.68% at 10 μM, respectively, and shows 5.747% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. Additionally, the compound inhibits human HDAC6 enzyme activity, with inhibition percentages of 63.68% and 8.47% in enzymatic assays. The compound's effects on cell viability vary based on cell type, demonstrating high growth rates in U2OS and HEK293T cells, and a wide range of growth rates in human fibroblast cells. This suggests differential bioactivities and potential cell-specific mechanisms of action..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3). |
| Targets&IC50 | TASK1/KCNK3:4 nM(thallium influx fluorescent assay)/16 nM(automated electrophysiology assay) |
| Molecular Weight | 360.41 |
| Formula | C22H20N2O3 |
| Cas No. | 947914-18-3 |
| Smiles | COc1ccccc1C(=O)Nc1cccc(NC(=O)c2cccc(C)c2)c1 |
| Relative Density. | 1.253 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (124.86 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.94 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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