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Hinokitiol

Name: Hinokitiol
Brand: TargetMol
SKU: T3717
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3717Cas No. 499-44-5

Alias β-thujaplicin, 4-Isopropyltropolone

Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent. Also, Hinokitiol modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells.

Hinokitiol

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Purity: 99.98%

Catalog No. T3717Alias β-thujaplicin, 4-IsopropyltropoloneCas No. 499-44-5

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$31	In Stock	In Stock
100 mg	$56	In Stock	In Stock
500 mg	$81	In Stock	In Stock
1 g	$98	-	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Hinokitiol AI Summary

Hinokitiol exhibits a wide range of bioactivities. It shows significant cytotoxicity against human KB, FM3A, KATO III, K562, and HL60 cells and mouse Ehrlich, MH134, and RL male 1 cells, with IC50 values ranging from 0.3 µg/mL to 3500.0 nM. Additionally, it demonstrates neuroprotective activity against glutamate-induced oxidative stress in mouse HT22 cells, with an EC50 of 4800.0 nM. The compound exhibits potent inhibitory activity against enzymes and proteins, including human recombinant MMPs, anthrax lethal factor, mushroom tyrosinase (IC50 of 90.0 nM), HIV-1 RT-RNase H domain, and SARS-CoV-2 3CL-Pro protease. It also shows antimicrobial activity against Propionibacterium acnes and antifungal activity with MIC values of 12.5 µg/mL for most fungi. It presents in vivo antitumor efficacy in P388 leukemia-bearing mice, with varying therapeutic effects at different doses. Hinokitiol also displays notable insecticidal and acaricidal activities against termites and dust mites, respectively. The compound has demonstrated in vivo antitumor activity in mouse models and shows potential as an HDAC inhibitor and antiviral agent against SARS-CoV-2. Furthermore, it influences various biological pathways, including lipid storage and DNA repair, suggesting its multifunctional potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity of metallothionein induced by the agent. Also, Hinokitiol modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells.
Synonyms	β-thujaplicin, 4-Isopropyltropolone

Chemical Properties

Molecular Weight	164.2
Formula	C₁₀H₁₂O₂
Cas No.	499-44-5
Smiles	C(C)(C)C=1C=C(O)C(=O)C=CC1
Relative Density.	1.127g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (1522.53 mM), Sonication is recommended.

Chloroform: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0901 mL	30.4507 mL	60.9013 mL	304.5067 mL
5 mM	1.2180 mL	6.0901 mL	12.1803 mL	60.9013 mL
10 mM	0.6090 mL	3.0451 mL	6.0901 mL	30.4507 mL
20 mM	0.3045 mL	1.5225 mL	3.0451 mL	15.2253 mL
50 mM	0.1218 mL	0.6090 mL	1.2180 mL	6.0901 mL
100 mM	0.0609 mL	0.3045 mL	0.6090 mL	3.0451 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc