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NF023 hexasodium

Name: NF023 hexasodium
Brand: TargetMol
SKU: TP2272
Rating: 4.5 (1 reviews)

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Catalog No. TP2272Cas No. 104869-31-0

Alias NF 023 hexasodium, NF 023

NF023 hexasodium is a selective and competitive P2X1 receptor antagonist with IC50 values of 0.21 μM, 28.9 μM, > 50 μM, and > 100 μM for human [P2X1], [P2X3], [P2X2], and [P2X4]-mediated responses, respectively.

NF023 hexasodium

😃Good

Catalog No. TP2272Alias NF 023 hexasodium, NF 023Cas No. 104869-31-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$649	35 days	35 days
25 mg	$1,420	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Orange

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Product Introduction

Bioactivity

Description	NF023 hexasodium is a selective and competitive P2X1 receptor antagonist with IC50 values of 0.21 μM, 28.9 μM, > 50 μM, and > 100 μM for human [P2X1], [P2X3], [P2X2], and [P2X4]-mediated responses, respectively.
In vitro	NF023 demonstrates selectivity for recombinant Gi alpha-1 and recombinant Go alpha, with an EC50 value around 300 nM. It inhibits P2X1 receptors independent of voltage changes. At concentrations of 5 and 30 μM, NF023 induces a rightward shift in the concentration-response curve for ATP without altering the maximal response, indicating an inhibitory effect with a KB value of 1.190.2 μM.
In vivo	NF023 (100 µmol/kg i.v.) inhibits vasopressor responses triggered by α,β-mATP without affecting those induced by noradrenaline in pithed rats [3].
Synonyms	NF 023 hexasodium, NF 023

Chemical Properties

Molecular Weight	1168.92
Formula	C₃₅H₂₆N₄Na₆O₂₁S₆
Cas No.	104869-31-0
Smiles	O=C(NC1=CC=CC(C(NC2=C3C(S(=O)(O)=O)=CC(S(=O)(O)=O)=CC3=C(S(=O)(O)=O)C=C2)=O)=C1)NC4=CC=CC(C(NC5=C6C(S(=O)(O)=O)=CC(S(=O)(O)=O)=CC6=C(S(=O)(O)=O)C=C5)=O)=C4.[Na].[Na].[Na].[Na].[Na].[Na]
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 105.3 mg/mL (90.08 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.8555 mL	4.2775 mL	8.5549 mL	42.7745 mL
5 mM	0.1711 mL	0.8555 mL	1.7110 mL	8.5549 mL
10 mM	0.0855 mL	0.4277 mL	0.8555 mL	4.2775 mL
20 mM	0.0428 mL	0.2139 mL	0.4277 mL	2.1387 mL
50 mM	0.0171 mL	0.0855 mL	0.1711 mL	0.8555 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc