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F16

Name: F16
Brand: TargetMol
SKU: T15266
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15266Cas No. 36098-33-6

Alias (E)-4-(3-indolylvinyl)-N-methylpyridinium iodide

F16 ((E)-4-(3-indolylvinyl)-N-methylpyridinium iodide) inhibits the growth of neu-overexpressing cells and the proliferation of mammary epithelial.

F16

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Purity: 99.89%

Catalog No. T15266Alias (E)-4-(3-indolylvinyl)-N-methylpyridinium iodideCas No. 36098-33-6

F16 ((E)-4-(3-indolylvinyl)-N-methylpyridinium iodide) inhibits the growth of neu-overexpressing cells and the proliferation of mammary epithelial.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	In Stock	In Stock
10 mg	$47	In Stock	In Stock
25 mg	$97	In Stock	In Stock
50 mg	$177	In Stock	In Stock
100 mg	$258	-	In Stock
200 mg	$389	-	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	F16 ((E)-4-(3-indolylvinyl)-N-methylpyridinium iodide) inhibits the growth of neu-overexpressing cells and the proliferation of mammary epithelial.
In vitro	F16 arrests the cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells. F16 (3 μM) influences growth in human and mice cancer cell lines[1]. F16 shows mitochondriotoxic property and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[2].
Synonyms	(E)-4-(3-indolylvinyl)-N-methylpyridinium iodide

Chemical Properties

Molecular Weight	362.21
Formula	C₁₆H₁₅IN₂
Cas No.	36098-33-6
Smiles	[I-].C[n+]1ccc(\C=C\c2c[nH]c3ccccc23)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (110.43 mM), Sonication is recommended.

Ethanol: 1 mg/mL (2.76 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7608 mL	13.8041 mL	27.6083 mL	138.0415 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5522 mL	2.7608 mL	5.5217 mL	27.6083 mL
10 mM	0.2761 mL	1.3804 mL	2.7608 mL	13.8041 mL
20 mM	0.1380 mL	0.6902 mL	1.3804 mL	6.9021 mL
50 mM	0.0552 mL	0.2761 mL	0.5522 mL	2.7608 mL
100 mM	0.0276 mL	0.1380 mL	0.2761 mL	1.3804 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc