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CHIR 98024
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Catalog No. T3074Cas No. 556813-39-9
Alias CHIR98014
CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
CHIR 98024
Copy Product Info🥰Excellent
Purity: 99.45%
Catalog No. T3074Alias CHIR98014Cas No. 556813-39-9
CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $37 | In Stock | In Stock | |
| 2 mg | $50 | In Stock | In Stock | |
| 5 mg | $97 | In Stock | In Stock | |
| 10 mg | $155 | In Stock | In Stock | |
| 25 mg | $313 | In Stock | In Stock | |
| 50 mg | $513 | In Stock | In Stock | |
| 100 mg | $743 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.45%
Appearance:Solid
Color:Yellow
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Product Introduction
CHIR 98024 AI Summary
CHIR 98024 is a potent inhibitor of GSK3-beta with an IC50 value of around 0.57 nM, and also effectively inhibits GSK3alpha with an IC50 of 0.65 nM. It displays moderate inhibitory activity against CDK1/cyclinB, with an IC50 value of 3700 nM. Additionally, CHIR 98024 shows less potent inhibitory activity towards a range of other kinases, with IC50 values greater than 5000 nM. Beyond its kinase inhibition profile, CHIR 98024 exhibits antidiabetic effects in diabetic mouse and rat models, showing reductions in plasma glucose AUC of 29.0% to 30.0% at various doses. The compound also has moderate oral bioavailability and stability in liver microsomes, presenting it as a promising candidate for further development as a diabetes therapeutic agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2. |
| Targets&IC50 | GSK-3β:0.58 nM, GSK-3:0.2566 μM (EC50), GSK-3α:0.65 nM |
| Synonyms | CHIR98014 |
| Molecular Weight | 486.31 |
| Formula | C20H17Cl2N9O2 |
| Cas No. | 556813-39-9 |
| Smiles | Nc1nc(NCCNc2ncc(-c3ncc[nH]3)c(n2)-c2ccc(Cl)cc2Cl)ccc1[N+]([O-])=O |
| Relative Density. | 1.573 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 6.88 mg/mL (14.15 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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