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XL413

Name: XL413
Brand: TargetMol
SKU: T3352
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3352 Copy Product Info

Purity: 99.94%

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XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells.

Cas No. 1169558-38-6

Pack Size	Price	USA Stock	Global Stock
1 mg	$48	In Stock	In Stock
5 mg	$118	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$297	In Stock	In Stock
50 mg	$496	-	In Stock
100 mg	$693	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

XL413 AI Summary

XL413 shows significant bioactivities, including the inhibition of key enzymes CDC7, PIM1, and CK2alpha, indicated by low IC50 values. It demonstrates antiproliferative effects and induces apoptosis in human Caco2 cells, along with antitumor activity in athymic nude mice xenografted with Caco2 cells, leading to tumor growth inhibition and regression at various dosages. This compound also shows drug uptake in tumor cells and minimal toxicity as indicated by negligible body weight loss at different dosages. Moreover, XL413 inhibits several cytochrome P450 enzymes, impacting drug metabolism. Its LogD7.4 value of 2.01 suggests a moderate distribution coefficient, and 92.8% plasma protein binding indicates high binding affinity. In antiviral research, XL413 inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells (47.61% at 10 µM after 48 hours) and in VERO-6 cells, albeit with much lower inhibition percentages. It also inhibits the SARS-CoV-2 3CL-Pro protease at 20 µM by approximately 14%. Furthermore, XL413 demonstrates inhibition of human HDAC6 enzyme activity, with varying levels of inhibition observed depending on the peptide substrate used in the assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells.
Targets & IC50	CK2:215nM, Pim1:42 nM, CDC7:3.4 nM, pMCM:118 nM(EC50)

Chemical Properties

Molecular Weight	289.72
Formula	C₁₄H₁₂ClN₃O₂
Cas No.	1169558-38-6
Smiles	O=C1C2=C(C=3C(O2)=CC=C(Cl)C3)NC(=N1)[C@@H]4CCCN4
Relative Density.	1.69 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.9 mg/mL (10.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 0.29 mg/mL (1 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4516 mL	17.2580 mL	34.5161 mL	172.5804 mL
5 mM	0.6903 mL	3.4516 mL	6.9032 mL	34.5161 mL
10 mM	0.3452 mL	1.7258 mL	3.4516 mL	17.2580 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc