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Oclacitinib maleate

Name: Oclacitinib maleate
Brand: TargetMol
SKU: T6914
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6914Cas No. 1640292-55-2

Alias PF-03394197 maleate, PF-03394197

Oclacitinib maleate (PF-03394197 maleate) is a novel inhibitor of JAK family members, with IC50 values ranging from 10 to 99 nM, and JAK1-dependent cytokines, with IC50 ranging from 36 to 249 nM, while not inhibiting a panel of 38 non-JAK kinases.

Oclacitinib maleate

🥰Excellent

Purity: 99.92%

Catalog No. T6914Alias PF-03394197 maleate, PF-03394197Cas No. 1640292-55-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
2 mg	$46	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$101	In Stock	In Stock
25 mg	$178	In Stock	In Stock
50 mg	$286	In Stock	In Stock
100 mg	$480	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.92%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Oclacitinib maleate (PF-03394197 maleate) is a novel inhibitor of JAK family members, with IC50 values ranging from 10 to 99 nM, and JAK1-dependent cytokines, with IC50 ranging from 36 to 249 nM, while not inhibiting a panel of 38 non-JAK kinases.
Targets&IC50	JAK1-dependent:36 to 249 nM, JAK:10 to 99 nM
In vitro	Oclacitinib inhibits JAK family members by 50% at concentrations ranging from 10 to 99 nM and does not inhibit a panel of 38 non-JAK kinases. Oclacitinib is most potent at inhibiting JAK1. Oclacitinib also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. Oclacitinib has minimal effects on cytokines which does not activate the JAK1 enzyme in cells[1].
In vivo	Oclacitinib administered orally at a dose of 0.4–0.6 mg/kg twice daily is safe and efficacious in controlling the pruritus associated with allergic dermatitis. Oclacitinib provides itch relief within 24 h that persistes through the treatment period, with over 70% of the treated dogs achieving a >50% reduction in pruritus by day 7[2].
Synonyms	PF-03394197 maleate, PF-03394197

Chemical Properties

Molecular Weight	453.51
Formula	C₁₅H₂₃N₅O₂S·C₄H₄O₄
Cas No.	1640292-55-2
Smiles	OC(=O)\C=C\C(O)=O.CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 15 mg/mL (33.08 mM), Sonication is recommended.

Ethanol: 83 mg/mL (183.02 mM), Sonication is recommended.

DMSO: 83 mg/mL (183.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.28 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2050 mL	11.0251 mL	22.0502 mL	110.2512 mL
5 mM	0.4410 mL	2.2050 mL	4.4100 mL	22.0502 mL
10 mM	0.2205 mL	1.1025 mL	2.2050 mL	11.0251 mL
20 mM	0.1103 mL	0.5513 mL	1.1025 mL	5.5126 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0441 mL	0.2205 mL	0.4410 mL	2.2050 mL
100 mM	0.0221 mL	0.1103 mL	0.2205 mL	1.1025 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc