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CB1R Allosteric modulator 3

Name: CB1R Allosteric modulator 3
Brand: TargetMol
SKU: T61562
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61562Cas No. 2633686-36-7

CB1R Allosteric modulator 3 is a potent CB1R modulator that inhibits cAMP and β-Arrestin and can be used for the study of obesity and nicotine addiction.

CB1R Allosteric modulator 3

🥰Excellent

Purity: 98.18%

Catalog No. T61562Cas No. 2633686-36-7

CB1R Allosteric modulator 3 is a potent CB1R modulator that inhibits cAMP and β-Arrestin and can be used for the study of obesity and nicotine addiction.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$57	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$243	In Stock	In Stock
100 mg	$361	-	In Stock
200 mg	$523	-	In Stock

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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

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Batch Information

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Purity:98.18%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	CB1R Allosteric modulator 3 is a potent CB1R modulator that inhibits cAMP and β-Arrestin and can be used for the study of obesity and nicotine addiction.
Targets&IC50	β-Arrestin:1.241 μM (EC50), cAMP:0.018 μM (EC50)
In vitro	At a duration of 30 minutes and concentrations ranging from 0.10 nM to 10 μM, CB1R Allosteric modulator 3 (compound 44) exhibits potent inhibition of cAMP and β-Arrestin, with EC50 values of 0.018 μM and 1.241 μM, respectively [1].Due to the presence of small lipophilic functional groups on the ortho-position of the GAT211 site-III phenyl ring, CB1R Allosteric modulator 3 can enhance CB1R ago-PAM activity [1].

Chemical Properties

Molecular Weight	376.84
Formula	C₂₂H₁₇ClN₂O₂
Cas No.	2633686-36-7
Smiles	C(CN(=O)=O)(C1=C(NC=2C1=CC=CC2)C3=CC=CC=C3)C4=C(Cl)C=CC=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (212.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6536 mL	13.2682 mL	26.5365 mL	132.6823 mL
5 mM	0.5307 mL	2.6536 mL	5.3073 mL	26.5365 mL
10 mM	0.2654 mL	1.3268 mL	2.6536 mL	13.2682 mL
20 mM	0.1327 mL	0.6634 mL	1.3268 mL	6.6341 mL
50 mM	0.0531 mL	0.2654 mL	0.5307 mL	2.6536 mL
100 mM	0.0265 mL	0.1327 mL	0.2654 mL	1.3268 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc