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CB1R Allosteric modulator 3

Name: CB1R Allosteric modulator 3
Brand: TargetMol
SKU: T61562
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61562Cas No. 2633686-36-7

CB1R Allosteric modulator 3 is a potent CB1R modulator that inhibits cAMP and β-Arrestin and can be used for the study of obesity and nicotine addiction.

CB1R Allosteric modulator 3

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Purity: 98.18%

Catalog No. T61562Cas No. 2633686-36-7

CB1R Allosteric modulator 3 is a potent CB1R modulator that inhibits cAMP and β-Arrestin and can be used for the study of obesity and nicotine addiction.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$57	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$163	In Stock	In Stock
50 mg	$243	In Stock	In Stock
100 mg	$361	-	In Stock
200 mg	$523	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.18%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	CB1R Allosteric modulator 3 is a potent CB1R modulator that inhibits cAMP and β-Arrestin and can be used for the study of obesity and nicotine addiction.
Targets&IC50	cAMP:0.018 μM (EC50), β-Arrestin:1.241 μM (EC50)
In vitro	At a duration of 30 minutes and concentrations ranging from 0.10 nM to 10 μM, CB1R Allosteric modulator 3 (compound 44) exhibits potent inhibition of cAMP and β-Arrestin, with EC50 values of 0.018 μM and 1.241 μM, respectively [1].Due to the presence of small lipophilic functional groups on the ortho-position of the GAT211 site-III phenyl ring, CB1R Allosteric modulator 3 can enhance CB1R ago-PAM activity [1].

Chemical Properties

Molecular Weight	376.84
Formula	C₂₂H₁₇ClN₂O₂
Cas No.	2633686-36-7
Smiles	C(CN(=O)=O)(C1=C(NC=2C1=CC=CC2)C3=CC=CC=C3)C4=C(Cl)C=CC=C4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (212.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6536 mL	13.2682 mL	26.5365 mL	132.6823 mL
5 mM	0.5307 mL	2.6536 mL	5.3073 mL	26.5365 mL
10 mM	0.2654 mL	1.3268 mL	2.6536 mL	13.2682 mL
20 mM	0.1327 mL	0.6634 mL	1.3268 mL	6.6341 mL
50 mM	0.0531 mL	0.2654 mL	0.5307 mL	2.6536 mL
100 mM	0.0265 mL	0.1327 mL	0.2654 mL	1.3268 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc