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CB1R Allosteric modulator 3

Catalog No. T61562 CAS 2633686-36-7

CB1R Allosteric modulator 3 is a potent CB1R modulator.CB1R Allosteric modulator 3 inhibits cAMP and β-Arrestin, and can be used for the study of obesity and nicotine addiction.

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CB1R Allosteric modulator 3 Chemical Structure

CB1R Allosteric modulator 3, CAS 2633686-36-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 970.00
10 mg	In stock	$ 1,200.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00

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Purity: 98.18%

Biological Description

Chemical Properties

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Description	CB1R Allosteric modulator 3 is a potent CB1R modulator.CB1R Allosteric modulator 3 inhibits cAMP and β-Arrestin, and can be used for the study of obesity and nicotine addiction.
Targets&IC50	cAMP:0.018 μM (EC50), β-Arrestin:1.241 μM (EC50)
In vitro	At a duration of 30 minutes and concentrations ranging from 0.10 nM to 10 μM, CB1R Allosteric modulator 3 (compound 44) exhibits potent inhibition of cAMP and β-Arrestin, with EC50 values of 0.018 μM and 1.241 μM, respectively [1].Due to the presence of small lipophilic functional groups on the ortho-position of the GAT211 site-III phenyl ring, CB1R Allosteric modulator 3 can enhance CB1R ago-PAM activity [1].

Molecular Weight	376.84
Formula	C22H17ClN2O2
CAS No.	2633686-36-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (212.29 mM), Sonication is recommended.

References and Literature

1. Peter C Schaffer, et al. Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility. Bioorg Med Chem. 2020 Nov 1;28(21):115727.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library

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Related compounds with same targets

GLP-1R modulator L7-028 Protopine hydrochloride Adenosine receptor A1 antagonist 5 TDI-10229 Bithionol I942 Licoarylcoumarin Catalponol

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Keywords

CB1R Allosteric modulator 3 2633686-36-7 GPCR/G Protein cAMP Cannabinoid Receptor inhibitor inhibit

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