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TargetMol | Tags Metabolism
TargetMol | Tags Neuroscience

MAO

Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines, employing oxygen to clip off their amine group. They are found bound to the outer membrane of mitochondria in most cell types of the body. MAOs are important in the breakdown of monoamines ingested in food, and also serve to inactivate monoamine neurotransmitters. Because of the latter, they are involved in a number of psychiatric and neurological diseases, some of which can be treated with monoamine oxidase inhibitors (MAOIs) which block the action of MAOs.

  • Ethaverine hydrochloride
    T0369985-13-7
    Ethaverine hydrochloride (Ethaquin) is a homologue of papaverine.
    • $30
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  • CX-157
    T15023205187-53-7In house
    CX-157 (KP 157) is a novel monoamine oxidase-A (MAO-A) inhibitor for the study of depression-like neurological disorders and cancer.
    • $293 TargetMol
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  • Hydroxyamine hydrochloride
    T115875470-11-1
    Hydroxyamine hydrochloride(Hydroxylammonium chloride) is a selective and potent monoamine oxidase (MAO) inhibitor with inhibitory effects on platelet aggregation.Hydroxyamine hydrochloridee is an intermediate in organic synthesis and can be used to synthesize other active compounds.
    • $39
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  • Safinamide mesylate
    T6651202825-46-5
    Safinamide mesylate (EMD 1195686 mesylate) , a mesylate salt of Safinamide, can reversibly and specifically inhibit MAO-B (IC50: 98 nM), has 5918-fold selectivity against MAO-A.
    • $36
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  • Sennoside A
    T096681-27-6
    Sennoside A (NSC-112929), a kind of irritant laxative isolated from rhei rhizome, causes purgative actions in the intestine.
    • $60
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  • Paeonol
    T2900552-41-0
    Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
    • $46
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  • Esuprone
    T2728891406-11-0In house
    Esuprone (LU-43839) is a novel reversible and highly selective MAO-A inhibitor with anticonvulsant activity for the treatment of depression.
    • $143
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  • 2614W94
    T10089205187-35-5In house
    2614W94 is a selective inhibitor of MAO-A with IC50 of 5 nM and Ki of 1.6 nM.
    • $151
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  • hMAO-B-IN-5
    T67879358343-63-2
    hMAO-B-IN-5 is a potent reversible and selective human monoamine oxidase hMAO-B inhibitor (IC50:0.12μM). hMAO-B-IN-5 can cross the blood-brain barrier and can be used in the study of Parkinson's disease. It is a promising compound in the treatment and diagnosis of central nervous system diseases.
    • $117
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  • AChE/BChE/MAO-B-IN-1
    T608912416910-82-0
    AChE BChE MAO-B-IN-1 is a reversible, non-time-dependent inhibitor of AChE, BChE and MAO-B that crosses the blood-brain barrier and exhibits inhibitory effects on hAChE, hBChE and hMAO-B with IC50s of 7.31, 0.56 and 26.1 μM, respectively. 1 had a neuroprotective effect and was not significantly cytotoxic.
    • $98
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  • Milacemide
    T5005576990-56-2
    Milacemide is a glycine prodrug and MAO-B inhibitor. Milacemide has been studied for its effects on human memory and as a potential treatment for the symptoms of Alzheimer's disease.
    • $58
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  • Indantadol HCl
    T27606202914-18-9
    Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.
    • $195
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  • CHBO4
    T7757898991-32-3
    CHBO4 is an hMAO-B inhibitor that is potent, reversible, competitive and selective.The IC50 value of CHBO4 against hMAO-B in the CHBO assay was 0.031 μM, and the Ki value was 0.010 ± 0.005 μM.CHBO4 reduces cellular damage by scavenging intracellular reactive oxygen species (ROS), and can be used to study Parkinson's disease (PD).
    • $52
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  • rosmarinate acid
    TN7057537-15-5
    Rosmarinate acid(Rosemary acid) inhibits MAO-A, MAO-B and COMT enzymes with IC50s of 50.1, 184.6 and 26.7 μM, respectively
    • $50
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  • PSB-1491
    T246801619884-67-1
    PSB-1491 is a selective and competitive monoamine oxidase B inhibitor with IC50 of 0.386 nM, >25000-fold selective versus MAO-A.
    • $48
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  • BW-1370U87
    T26930134476-36-1In house
    BW-1370U87 is a reversible competitive monoamine oxidase-A inhibitor for the study of depression and other CNS disorders.
    • $293 TargetMol
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  • Atibeprone
    T71934153420-96-3In house
    Atibeprone is a MAO-B inhibitor with antidepressant activity for the study of Parkinson's disease.
    • $80 TargetMol
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  • AnnH31
    T26632241809-12-1
    AnnH31 is a potent Dyrk1A inhibitor with an IC50 value of 81 nM.AnnH31 inhibits MAO-A with an IC50 of 3.2 μM.AnnH31 can be used as a probe to confirm the involvement of DYRK1A in cellular phosphorylation.
    • $213
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  • Tetrindole mesylate
    T23453170964-68-8
    Tetrindole mesylate is a MAO-A inhibitor.
    • $128
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  • Ladostigil
    T32535209394-27-4In house
    Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 values of 37.1 and 31.8 μM, respectively.Ladostigil possesses anti-inflammatory, antioxidant, and neuroprotective activities, and may be used in studies of depression and Alzheimer's disease.
    • $120
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  • Bazinaprine
    T6778994011-82-2In house
    Bazinaprine is a selective, reversible monoamine oxidase inhibitor (MAOI) that is a candidate compound for the treatment of depression. Bazinaprine showed strong inhibitory effect on type A monoamine oxidase and weak inhibitory effect on type b monoamine oxidase. Bazinaprine is reversible in vivo, but not in vitro.
    • $154
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  • CR4056
    T150101004997-71-0
    CR4056 (6-(1H-imidazol-1-yl)-2-phenylquinazoline) is a selective inhibitor of MAO-A with IC50 of 202.7 nM and a ligand of I2-imidazoline receptor with IC50 of 596 nM.
    • $195
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  • Sembragiline
    T28750676479-06-4In house
    Sembragiline (EVT-302) is a selective MAO-B inhibitor for the study of Alzheimer's disease (AD).
    • $998 TargetMol
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  • FCE 28073
    T67850174756-44-6
    FCE 28073 is a Monoamine oxidase B inibitor with IC50 of 0.45 uM.
    • $33
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  • PSB-1434
    T246791619884-65-9
    PSB-1434 is a selective and competitive monoamine oxidase B inhibitor.
    • $148
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  • (Z)-SU4312
    T567690828-16-3
    (Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).
    • $133
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  • Raloxifene hydrochloride
    T154982640-04-8
    Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
    • $38
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  • Salvigenin
    TMS174319103-54-9
    Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.
    • $65
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  • Rosmarinic acid
    T276520283-92-5
    Rosmarinic acid (Labiatenic acid) is widely found in plants and has antioxidant, anti-inflammatory, and antibacterial activities. It inhibits MAO-A, MAO-B, and COMT with IC50 of 50.1, 184.6, and 26.7 μM respectively.
    • $33
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  • Jatrorrhizine
    T39333621-38-3
    Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).
    • $50
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  • Nialamide
    T145551-12-7
    Nialamide (Nialamid) is an MAO inhibitor that is used as an antidepressive agent.
    • $50
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  • Pargyline
    T0300555-57-7
    Pargyline (Pargylamine) is a monoamine oxidase inhibitor with antihypertensive properties.
    • $48
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  • Harmine
    T1711442-51-3
    Harmine (Telepathine) is an alkaloid isolated from seeds of Peganum harmala.
    • $30
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  • Glycyrrhizic acid
    T27411405-86-3
    Glycyrrhizic acid (Glycyrrhizin) is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
    • $29
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  • 1,4-Naphthoquinone
    T7048130-15-4
    1,4-Naphthoquinone (P-Naphthoquinone) was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].
    • $31
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  • Furazolidone
    T075167-45-8
    Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. It is antibacterial and antiprotozoal activity,
    • $40
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  • hMAO-B-IN-32
    T7823228705-46-6
    hMAO-B-IN-32 is a potent hMAO-B selective inhibitor with an IC50 of 45.52 μM.
    • $33
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  • PF-9601N
    T8849133845-63-3
    PF-9601N showed high potency and selectivity as a MAO-BI (monoamine oxidase type B inhibitor) and also demonstrated remarkable neuroprotective properties in several in vivo and cellular models of PD.
    • $31
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  • 2'-O-Methylperlatolic acid
    TN279038968-07-9
    2'-O-Methylperlatolic acid and confluentic acid are monoamine oxidase B inhibitors in a Brazilian plant, Himatanthus sucuuba.
    • $620
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  • WAY-620147
    T80799515866-67-8
    WAY-620147 is a derivative of N-(2-morpholinoethyl)nicotinamide, which is able to inhibit Monoamine Oxidase.WAY-620147 has an IC50 value of 26 μM for MAO-A and 55 μM for MAO-B, and can be used for the study of neurological diseases.
    • $30
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  • Eprobemide
    T505387940-60-1
    Eprobemide (LIS 630) is a non-competitive reversible inhibitor of monoamine oxidase A (MAO-A).
    • $33
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  • Cudraflavone B
    TN372619275-49-1
    Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. It may be a lead for the development of a potential candidate for human oral squamous cell carcinoma cells.
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  • 7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
    T588722246-18-0
    7-Hydroxy-3,4-dihydro-2(1H)-quinolinone is a weak MAO-A inhibitor(with an IC50 of 183 μM) .
    • $29
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  • Glicoricone
    TN4137161099-37-2
    Glicoricone acts as a partial estrogen antagonist. Glicoricone inhibited the monoamine oxidase with the IC50 values of 6.0 x 10(-5)-1.4 x 10(-4) M.
    • $814
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  • Azure B
    T18918531-55-5
    Azure B (Azure B chloride) is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombinant human MAO-A and MAO-B).
    • $213
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  • Bifemelane hydrochloride
    T2260562232-46-6
    Bifemelane hydrochloride is a MAO inhibitor
    • $35
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  • (±)-Amiflamine
    T858977502-96-6
    (±)-Amiflamine (2-dimethylphenethylamine) is an inhibitor of reversible MAO-A.
    • $34
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  • Iproniazid Phosphate
    T0821305-33-9
    Iproniazid Phosphate is a non-selective, irreversible monoamine oxidase inhibitor (MAOI).
    • $30
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  • 4'-Demethyleucomin
    TN302434818-83-2
    4'-Demethyleucomin is a natural product for research related to life sciences. The catalog number is TN3024 and the CAS number is 34818-83-2.
    • $276
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  • MAO-B-IN-30
    T8430982973-15-7
    MAO-B-IN-30 is a selective and potent MAO-B inhibitor that crosses the blood-brain barrier with antiproliferative activity and inhibits both MAO-A and MAO-B.MAO-B-IN-30 reduces the levels of TNF-alpha, IL-6, and NF-kB in organisms, and can be used to study Parkinson's-type neurological disorders.
    • $40
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