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2-amino-4-methyl-1,3-thiazole-5-carbohydrazide

Name: 2-amino-4-methyl-1,3-thiazole-5-carbohydrazide
Brand: TargetMol
SKU: T50016
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T50016Cas No. 63788-59-0

2-amino-4-methyl-1,3-thiazole-5-carbohydrazide (AMTCH) has antitumor activity and inhibits the growth of cancer cells by inducing apoptosis or programmed cell death. It also has antibacterial and fungal activity.

2-amino-4-methyl-1,3-thiazole-5-carbohydrazide

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Purity: 97.55%

Catalog No. T50016Cas No. 63788-59-0

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$54	In Stock	In Stock
50 mg	$81	In Stock	In Stock
100 mg	$120	In Stock	In Stock
200 mg	$181	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.55%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

2-amino-4-methyl-1,3-thiazole-5-carbohydrazide AI Summary

2-amino-4-methyl-1,3-thiazole-5-carbohydrazide exhibits a variety of bioactivities with varying potencies. It acts as an inhibitor of Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 25118.9 nM, Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) with a potency of 44668.4 nM, JMJD2A-Tudor Domain with a potency of 14125.4 nM, and has UBC13 Polyubiquitin inhibitor actions via a TR-FRET Assay with an IC50 greater than 20000.0 nM. Additionally, it inhibits Chronic Active B-Cell Receptor Signaling with a potency of 631.0 nM, BAZ2B with a potency of 89125.1 nM, and Polymerase Iota with the same potency of 89125.1 nM. The compound also exhibits delayed death inhibition of the malarial parasite plastid with potencies ranging from 5221.3 nM to 14715.7 nM, and induces DNA re-replication in SW480 colon adenocarcinoma cells with a potency of 163.6 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	172.21
Formula	C₅H₈N₄OS
Cas No.	63788-59-0
Smiles	CC1=C(SC(N)=N1)C(=O)NN
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (319.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.8069 mL	29.0343 mL	58.0686 mL	290.3432 mL
5 mM	1.1614 mL	5.8069 mL	11.6137 mL	58.0686 mL
10 mM	0.5807 mL	2.9034 mL	5.8069 mL	29.0343 mL
20 mM	0.2903 mL	1.4517 mL	2.9034 mL	14.5172 mL
50 mM	0.1161 mL	0.5807 mL	1.1614 mL	5.8069 mL
100 mM	0.0581 mL	0.2903 mL	0.5807 mL	2.9034 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

2-amino-4-methyl-1,3-thiazole-5-carbohydrazide2amino4methyl1,3thiazole5carbohydrazide2 amino 4 methyl 1,3 thiazole 5 carbohydrazide

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