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K-7174 dihydrochloride

🥰Excellent
Catalog No. T11742LCas No. 191089-60-8
Alias K-7174 2HCl, K7174 2HCl, K 7174 2HCl

K-7174 dihydrochloride is a proteasome and GATA inhibitor that inhibits neuronal degeneration and induces apoptosis.

K-7174 dihydrochloride
Other Forms of K-7174 dihydrochloride:
K-7174T11742191089-59-5
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K-7174 dihydrochloride

🥰Excellent
Purity: 99.15%
Catalog No. T11742LAlias K-7174 2HCl, K7174 2HCl, K 7174 2HClCas No. 191089-60-8
K-7174 dihydrochloride is a proteasome and GATA inhibitor that inhibits neuronal degeneration and induces apoptosis.
Pack SizePriceAvailabilityQuantity
1 mg$30In Stock
5 mg$64In Stock
10 mg$106In Stock
25 mg$177In Stock
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Batch Information

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Purity:99.15%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
K-7174 dihydrochloride is a proteasome and GATA inhibitor that inhibits neuronal degeneration and induces apoptosis.
In vitro
In KMS12-BM, U266, and RPMI8226 cell lines, K-7174 dihydrochloride (0-25 μM; 72 hours) inhibited the growth of multiple myeloma cells[3].
In vivo
In ICR mice injected with IL-β or TNF-α, K-7174 dihydrochloride (30 mg/kg; intraperitoneal injection; once daily for 9 days) increased erythropoietin (Epo) production, reticulocyte counts, and hemoglobin (Hb) concentrations[2].
SynonymsK-7174 2HCl, K7174 2HCl, K 7174 2HCl
Chemical Properties
Molecular Weight641.67
FormulaC33H50Cl2N2O6
Cas No.191089-60-8
SmilesCl.Cl.COc1cc(\C=C\CCCN2CCCN(CCC\C=C\c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 15 mg/mL (23.38 mM), Sonication and heating are recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.5584 mL7.7922 mL15.5843 mL77.9217 mL
5 mM0.3117 mL1.5584 mL3.1169 mL15.5843 mL
10 mM0.1558 mL0.7792 mL1.5584 mL7.7922 mL
20 mM0.0779 mL0.3896 mL0.7792 mL3.8961 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

proteasomeK-7174 DihydrochlorideK-7174K7174K 7174
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