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K-7174 dihydrochloride

🥰Excellent
Catalog No. T11742LCas No. 191089-60-8
Alias K-7174 2HCl, K7174 2HCl, K 7174 2HCl

K-7174 dihydrochloride is a proteasome and GATA inhibitor that inhibits neuronal degeneration and induces apoptosis.

K-7174 dihydrochloride
Other Forms of K-7174 dihydrochloride:
K-7174T11742191089-59-5
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K-7174 dihydrochloride

🥰Excellent
Purity: 99.15%
Catalog No. T11742LAlias K-7174 2HCl, K7174 2HCl, K 7174 2HClCas No. 191089-60-8
K-7174 dihydrochloride is a proteasome and GATA inhibitor that inhibits neuronal degeneration and induces apoptosis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30-In Stock
5 mg$64In StockIn Stock
10 mg$106In StockIn Stock
25 mg$177In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:99.15%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
K-7174 dihydrochloride is a proteasome and GATA inhibitor that inhibits neuronal degeneration and induces apoptosis.
In vitro
In KMS12-BM, U266, and RPMI8226 cell lines, K-7174 dihydrochloride (0-25 μM; 72 hours) inhibited the growth of multiple myeloma cells[3].
In vivo
In ICR mice injected with IL-β or TNF-α, K-7174 dihydrochloride (30 mg/kg; intraperitoneal injection; once daily for 9 days) increased erythropoietin (Epo) production, reticulocyte counts, and hemoglobin (Hb) concentrations[2].
SynonymsK-7174 2HCl, K7174 2HCl, K 7174 2HCl
Chemical Properties
Molecular Weight641.67
FormulaC33H50Cl2N2O6
Cas No.191089-60-8
SmilesCl.Cl.COc1cc(\C=C\CCCN2CCCN(CCC\C=C\c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 15 mg/mL (23.38 mM), Sonication and heating are recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM1.5584 mL7.7922 mL15.5843 mL77.9217 mL
5 mM0.3117 mL1.5584 mL3.1169 mL15.5843 mL
10 mM0.1558 mL0.7792 mL1.5584 mL7.7922 mL
20 mM0.0779 mL0.3896 mL0.7792 mL3.8961 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

proteasomeK-7174 DihydrochlorideK-7174K7174K 7174
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