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CGP 35348

Name: CGP 35348
Brand: TargetMol
SKU: T21793
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21793Cas No. 123690-79-9

CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice.

CGP 35348

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Purity: 99.92%

Catalog No. T21793Cas No. 123690-79-9

CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$328	In Stock	In Stock
50 mg	$529	In Stock	In Stock
100 mg	$793	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CGP 35348 is a selective antagonist of GABAB receptor (EC50 = 34 μM). CGP 35348 can be used in studies of neuromuscular coordination and spatial learning after neonatal brain damage in albino mice.
In vivo	In male Wistar rats, CGP 35348(100, 300, and 900 mg/kg) produced an increase in the duration of non-REM sleep and rapid eye movement (REM) sleep and reduced strongly spike-wave discharges[2].

Chemical Properties

Molecular Weight	225.22
Formula	C₈H₂₀NO₄P
Cas No.	123690-79-9
Smiles	C(P(CCCN)(=O)O)(OCC)OCC
Relative Density.	1.131g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 83.3 mg/mL (369.86 mM), Sonication is recommended.

DMSO: < 2.25 mg/mL (10 mM, insoluble or slightly soluble)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.4401 mL	22.2005 mL	44.4010 mL	222.0052 mL
5 mM	0.8880 mL	4.4401 mL	8.8802 mL	44.4010 mL
10 mM	0.4440 mL	2.2201 mL	4.4401 mL	22.2005 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.2220 mL	1.1100 mL	2.2201 mL	11.1003 mL
50 mM	0.0888 mL	0.4440 mL	0.8880 mL	4.4401 mL
100 mM	0.0444 mL	0.2220 mL	0.4440 mL	2.2201 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc