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Amantadine
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Catalog No. T7060Cas No. 768-94-5
Alias 1-Aminoadamantane, 1-Adamantylamine, 1-Adamantanamine
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.
Amantadine
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Purity: 99.94%
Catalog No. T7060Alias 1-Aminoadamantane, 1-Adamantylamine, 1-AdamantanamineCas No. 768-94-5
Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 g | $31 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.94%
Appearance:Solid
Color:White
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Product Introduction
Amantadine AI Summary
Amantadine exhibits significant antiviral activity against various strains of Influenza A and B viruses, demonstrating inhibition of virus-induced cytopathic effects in MDCK cells with EC50 values ranging from 1900.0 nM to over 100000.0 nM. This compound showslow cytotoxicity against MDCK cells, with CC50 values exceeding 500000.0 nM, indicating a high therapeutic window. Additionally, Amantadine targets the M2 ion channel protein of the influenza virus, showing potent inhibition against both wild-type and amantadine-resistant strains. It also demonstrates antiviral efficacy in reducing virus-induced cytopathic effects in cell-based assays and maintains cell viability, which further supports its potential as a therapeutic agent against influenza viruses. Moreover, the compound has a calculated pKa value around 10.65, a partition coefficient (logP) of 2.44, and exhibits a high oral bioavailability of 79%. It also demonstrates moderate clearance and a high volume of distribution, suggesting good systemic availability and tissue penetration. Preliminary studies have also identified its binding affinity towards sigma receptors in guinea pig brain membranes and its antagonist activity at NMDA receptors, indicating potential utility beyond antiviral applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Amantadine (1-Aminoadamantane) is an antiviral, is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. |
| Synonyms | 1-Aminoadamantane, 1-Adamantylamine, 1-Adamantanamine |
| Molecular Weight | 151.25 |
| Formula | C10H17N |
| Cas No. | 768-94-5 |
| Smiles | NC12CC3CC(CC(C3)C1)C2 |
| Relative Density. | 0.894 g/cm3. Temperature:20 °C. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 22.7 mg/mL (150.08 mM), , when pH is adjusted to 3 with HCl. Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Vero E6 cellsSMMC?7721SARS-CoVSARS coronavirusPostoperative cognitive dysfunctionPOCDParkinson's diseaseOrthopoxvirusNeuroinflammationmemory impairmentM2 proton channelliver cancerInhibitorinhibitInfluenza VirusHepG2hepatitis C virusHCC cellsCyclin dependent kinaseCovid-19CDKBcl-2 FamilyApoptosisantiviral drugsantiviralanticancerAmantadine
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