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ELA-14(human) acetate

Name: ELA-14(human) acetate
Brand: TargetMol
SKU: TP1923L1
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1923L1

Alias ELA-14(human) acetate (1886973-05-2 free base)

ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.

ELA-14(human) acetate

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Purity: 97.2%

Catalog No. TP1923L1Alias ELA-14(human) acetate (1886973-05-2 free base)

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	-	In Stock
5 mg	$128	-	In Stock
10 mg	$192	-	In Stock
25 mg	$311	-	In Stock
50 mg	$428	-	In Stock
100 mg	$569	-	In Stock
200 mg	$762	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.2%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the Gαi1 and β-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.
Targets&IC50	Gαi1:8.6 nM(EC50), β-arrestin2:166 nM(EC50)
In vitro	ELA-14 activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. ELA-14 induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].
In vivo	ELA-14 is rapidly metabolized in rat plasma (t1/2<2 min)[1].
Synonyms	ELA-14(human) acetate (1886973-05-2 free base)

Chemical Properties

Molecular Weight	1767.09
Formula	C₇₇H₁₂₃N₂₅O₁₉S₂
Smiles	CC(C)C[C@@H](C(N[C@@H](Cc1c[nH]cn1)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N(CCC1)[C@@H]1C(N[C@@H](Cc1ccccc1)C(N(CCC1)[C@@H]1C(O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCC1)N1C([C@H](CCSC)NC([C@H](CS)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC1)NC1=O)=O)=O)=O)=O)=O)=O.CC(O)=O
Relative Density.	no data available
Sequence	Pyr-Arg-Arg-Cys-Met-Pro-Leu-His-Ser-Arg-Val-Pro-Phe-Pro
Sequence Short	XRRCMPLHSRVPFP

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (56.59 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.5659 mL	2.8295 mL	5.6590 mL	28.2951 mL
5 mM	0.1132 mL	0.5659 mL	1.1318 mL	5.6590 mL
10 mM	0.0566 mL	0.2830 mL	0.5659 mL	2.8295 mL
20 mM	0.0283 mL	0.1415 mL	0.2830 mL	1.4148 mL
50 mM	0.0113 mL	0.0566 mL	0.1132 mL	0.5659 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc