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Anti-PAI-1 Polyclonal Antibody is a Rabbit antibody targeting PAI-1. Anti-PAI-1 Polyclonal Antibody can be used in ICC/IF,WB.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $220 | 7-10 days | |
100 μL | $372 | 7-10 days | |
200 μL | $529 | 7-10 days |
Description | Anti-PAI-1 Polyclonal Antibody is a Rabbit antibody targeting PAI-1. Anti-PAI-1 Polyclonal Antibody can be used in ICC/IF,WB. |
Synonyms | SERPINE1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1, PLANH1, PAI-1, PAI1, PAI |
Ig Type | IgG |
Reactivity | Human,Mouse,Rat (predicted:Dog,Pig,Cow,Rabbit,Sheep) |
Verified Activity | 1. A549 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Antibody incubation with (PAI1) polyclonal Antibody, Unconjugated (TMAB-01327) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue) was used to stain the cell nucleus. 2. A549 cell; 4% Paraformaldehyde-fixed; Triton X-100 at room temperature for 20 min; Blocking buffer (normal goat serum) at 37°C for 20 min; Antibody incubation with (PAI1) polyclonal Antibody, Unconjugated (TMAB-01327) 1:100, 90 minutes at 37°C; followed by a conjugated Goat Anti-Rabbit IgG antibody at 37°C for 90 minutes, DAPI (blue) was used to stain the cell nucleus. 3. Sample: Lane 1: Mouse Lung tissue lysates Lane 2: Rat Lung tissue lysates Primary: Anti-PAI1 (TMAB-01327) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 43 kDa Observed band size: 46 kDa |
Application | |
Recommended Dose | WB: 1:500-2000; ICC/IF: 1:100 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Subcellular Localization | Secreted |
Tissue Specificity | Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells |
Construction | Polyclonal Antibody |
Purification | Protein A purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Concentration | 1 mg/mL |
Research Background | PAI1 (plasminogen activator inhibitor 1) is originally cloned from human endothelial cell (Pannekoek 1986, Ginsburg 1986) and rat hepatoma cell 3 cDNA libraries. As a member of the serpin family of serine protease inhibitors, PAI1 inhibits both tissue type plasminogen activator (tPA) and urokinase type plasminogen activator (uPA). High PAI1 levels are associated with an increased risk of thromboembolic disease while PAI1 deficiency may represent an inherited autosomal recessive bleeding disorder. |
Immunogen | KLH conjugated synthetic peptide: human PAI-1 |
Antigen Species | Human |
Gene Name | SERPINE1 |
Gene ID | |
Protein Name | Plasminogen activator inhibitor 1 |
Uniprot ID | |
Function | Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis. |
Molecular Weight | Theoretical: 43 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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